Ipamorelin Effects and Efficacy

Ipamorelin Effects and Efficacy

Ipamorelin is a secretagogue peptide, implying that it plays an important role in the control of body homeostasis and weight. The peptide is known to accentuate the release of growth hormone from the anterior lobe of the pituitary gland. The peptide is a new wave in the growth hormone releasing peptides category. It has enhanced potency and long-lasting effect than the naturally produced peptide and it has a better efficacy than its predecessors GHRP-2 and GHRP-6 do. Ipamorelin is a is pentapeptide with amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 and a molecular mass of 0.711 Daltons. Nevertheless, the peptide is very powerful and aids the release of the growth hormone from the pituitary gland. The molecular weight of the peptide has substantially increased muscle growth and improved fat burning ability simultaneously. It is classified as growth hormone releasing peptides or what is commonly called GHRPs.

This category of peptide is essential in accentuating the release of growth hormone from the pituitary gland. Similarly, the growth hormone releasing hormone or GHRH have shown to have a positive feedback mechanism in the release of growth hormone from the somatotropes located in the pituitary gland. The peptides are important in accentuating somatotropes to produce and distribute the hormone to the target receptors in the body of the organism. The secretion of the growth hormone from the pituitary cells on the anterior lobe was discovered in the early 1990s. The secretion of the peptide from the pituitary cells has attracted numerous researchers since hormonal deficiency and failure of receptors to get the hormone has caused various challenges.

Ipamorelin Dosage

ipamorelin dosage
ipamorelin dosage

The recommended dosage of ipamorelin is from 200 milligrams to 300 milligrams and it can be administered 2-3 times a day with a little insulin if need be. However, for research purposes 200 milligrams to 300 milligrams is the recommended dosage. An increase in dosage does not increase the production of the peptide. it will reach a point where the production of the peptide has peaked and cannot be enhanced through hormonal modification.

Some ipamorelin side effects seen in mice and other test rodents are head rushes and headaches. Ipamorelin is one of the cleanest, safest and cleanest growth releasing peptide in the market. According to research, the peptide improves moods and sleep as shown by the rodents used in the study. However, it is imperative to note that these peptides are for research purposes only and human consumption has not been approved. On the hunger part, it is crucial to understand that ipamorelin does not have any effect on gastric motility, gastric emptying and feeling of hunger. Since the studies on potency, efficacy and effectiveness of the peptide are still under investigation, you should only buy ipamorelin for research purposes only. Ipamorelin has no effect on the level of prolactin and cortisol in the system and on the levels of acetylcholine.

Mechanism of Action

Mechanism of action
Mechanism of action

There are numerous studies which indicated that ipamorelin has an effect on bone growth, weight and the production of growth hormone. It is one of the most efficient peptides in the release of growth hormone from the anterior lobe of the pituitary gland. It is a biosynthetic hormone that can be used to accentuate the release of growth hormone from pituitary cells on the anterior lobe. The mode of action is through biomimicry as the peptide is an endogenous hormone which acts like Ghrelin. However, unlike growth hormone releasing hexapeptide, it is more stable in suppressing the effects of somatostatin and releasing growth hormone at a steady pace. There are findings that make ipamorelin one of the best peptides in releasing growth hormone because it does not induce hunger and produces the hormone at a steady pace.

Once ipamorelin is administered, it can stay active at optimal level for up to 3 hours. The pulse is then sent from the point of origin to the desired receptor. Once the signaling cascade has been triggered, it then moves to the cell where it supports muscle development and avoids interference with bone growth or cartilage. This is beneficial because it may promote lean body mass and accentuates muscle growth with the possibility of improving performance. Compared to the synthetic human growth hormone, ipamorelin is preferred because it does not cause the swelling of joints and carpal tunnel syndrome. The peptide has shown the ability to boost cell synthesis, boost Ghrelin level in the stomach and increase insulin secretion from the pancreatic tissue. Collectively, all these activities are important in facilitating the transportation of nutrients while aiding fat loss and development of lean muscles. Ipamorelin increases cell synthesis, development and maturity. Moreover, it elevates the levels of insulin from and Ghrelin from stomach lining. All these processes are important in shuttling of nutrients and building of lean muscle mass.

Side effects of ipamorelin

Side effects of ipamorelin
Side effects of ipamorelin

The side effects of ipamorelin results can be observed from experimental studies done on rodents and other test organisms. Ipamorelin is considered as one of the safest peptides as it only targets the growth hormone releasing sites without having any effect on the levels of LH, TSH, and PRL. FSH and prolactin levels in the plasma unlike other peptides such as growth hormone releasing hexapeptide or GHRP-2. When the level of ipamorelin is high in the system, it can cause a sudden increase in the levels of cortisol and acetylcholine. However there are very few reports that back up this kind of data.

Just like other peptides, ipamorelin is supplied in powder in a vial. It should be reconstituted using bacteriostatic water or sodium chloride. It is important to note that you should only reconstitute the amount you need and not more. This is crucial because reconstituting the entire vial may cause it to lose its integrity or reduce its optimal function. Once teh vial is opened, keep it in the freezer of between 2 and8 degrees Celsius. Always ensure that the storage place is cool, dry and away from sunlight as heat changes these parameters and may cause the vial to lose its integrity.