Ipamorelin Suggested Uses and Ongoing Experiments
Ipamorelin is a polypeptide that is classified as a secretagogue. Secretagogues play an essential role in controlling the weight and energy homeostasis in organisms. The peptide is similar to the growth hormone releasing hexapeptide. The main difference is that ipamorelin is made up of five amino acids while growth hormone releasing hexapeptide is made up of six amino acids. Ipamorelin has five amino acids in its chain and has a molecular mass of 711.85296 Daltons. Since it is an agonist , it has the ability to bind to certain receptors in the cell and provoke a cellular response. Recent research has shown that ipamorelin works by stimulating the anterior pituitary gland to release the growth hormone. This has been an area of interest as many scientists are looking for avenues to manipulate the peptide to bring about positive benefits.
Recent Research on Ipamorelin
According to recent scientific research conducted on test animal subjects, the primary function of ipamorelin is to stimulate the pituitary gland. The pea-sized gland is located below the hypothalamus and its main functions are regulating body growth, blood pressure, thyroid function as well as temperature and pain relief. The main action is the stimulation of the production of the growth hormone. Ipamorelin has shown to be the finest and cleanest peptide compared to its predecessors such as GHRP-6 and GHP-2 in the production of growth hormone. Ipamorelin has shown to be effective as one of the growth hormone side effects is to inhibit the functionality of somatostatin. Somatostatin is a peptide that is produced concurrently alongside growth hormone. Moreover, the peptide has shown the ability to increase the production of insulin-like growth factor 1 and this essential because it promotes cellular development and multiplication of cells.
Ipamorelin and Bone Density
Research is underway to determine the efficacy of using ipamorelin to accentuate the development of bones and to determine whether the peptide can induce bone mineral density. The development of bone mineral density is an essential process which relies on the production of growth hormone from the anterior lobe of the pituitary gland. Growth hormone effects include modeling and remodeling of the osteoclasts. According to research conducted on mice, ipamorelin injection resulted in an increase in the longitudinal growth and an increased subperiosteal bone deposition. Studies indicated that the injection of ipamorelin on test organisms will lead to an increased bone density. Images obtained from scanning the bones of the mice after the peptide was injected indicated that there was an increase in bone mass and density. Moreover, for mice that have growth hormone deficiency, the injection of ipamorelin has shown to boost the levels of growth hormone and this reduces chances of poor bone formation and bone fractures.
Studies are still underway and ipamorelin effects on the bone mineral density of the organism is a key area of interest. Research findings have shown that growth hormone has a major effect on bone mineral density through the stimulatory effect on the weight bearing skeletal locations. The mechanism of stimulation is through the inhibition of somatostatin and the accentuation of the natural production of growth hormones from the somatotrophs. Normal bone metabolism is usually regulated by a balance between bone resorption and osteoclasts formation. These two processes are essential in determining the density of the bones and the strength as well. Osteoblasts cells are directly responsible for bone formation and they control bone resorption through the regulation of proliferation, differentiation and the recruitment of osteoclasts progenitors. The research findings show that ipamorelin has a direct stimulatory effect on growth hormone and bone formation. In addition, the pituitary gland secretion of the growth hormone is regulated by growth hormone releasing hormone and inhibited by somatostatin.
The new class of synthetic growth hormone secretagogues such as ipamorelin has G-coupled protein effect on the working mechanism of the growth hormone release. At the hypothalamus, the growth hormone secretagogue stimulates the secretion of the growth hormone by activating the arcuate nucleus growth hormone-releasing hormone neurons. The growth hormone secretagogues also have a direct action on the pituitary gland because it deters the activity of somatostatin. The stimulatory effect of the growth hormone by ipamorelin means that the peptide has a potential effect in increasing bone mineral density. When the amplitude of GH release pulses are increased,bone density of the mice increased, this shows that the peptide has a positive feedback on the mineral density and bone growth.
Ipamorelin and Weight Loss
The side effects of ipamorelin include enhancing gastric motility and gastric emptying. Since the peptide has the ability to bind to major control points of appetite, gastric motility, and gastric emptying the peptide has the ability to induce weight loss. According to research conducted on mice when the peptide was injected the mice showed a reduced appetite and the research shows that an increase in the levels of growth hormone in the system is essential in accentuating weight loss. Growth hormone is known to accentuate metabolism, and metabolism is key when it comes to the burning of excess fats in the system.
When the peptide is injected to the test organism, the burning of fats increased, the mice weighed less when compared to their previous weights before the peptide was administered. In addition, a high level of the growth hormone in the system helps in the recovery process because the muscles cells are able to regenerate easily. This is also beneficial in weight loss if the mice are subjected to vigorous exercises. Ipamorelin is an effective peptide in increasing the production of growth hormone and the loss of fats from the peripheral and visceral organs. In most cases, it is recommended that you administer 200-300mcg during the experiment and you can increase the dosage or reduce depending on the tolerance of the organism. Ipamorelin is still under research for other postulated benefits and scientists are coming up with ways of manipulating the peptide to increase its potency and efficacy.