Differences between Melanotan 1 and 2

Differences between Melanotan 1 and 2

Differences
Differences

A peptide is a chain of amino acids, which are linked to one another via peptide or amide bonds. The peptide bond is a covalent chemical bond that is formed when the amino group of one amino acid reacts with the carboxyl group of the next amino acid. Peptides form an integral part of the functioning of a biological system. They perform various functions such as muscle growth, neurotransmission, aid in alleviating hormonal deficiency and enhance neurological functions, among others. Peptides are synthesized both naturally and synthetically and because of the efficacy of production, synthetic peptides are under research and study to determine their modes of activity.

Melanotan 1 or afamelanotide is a synthetic variation of the naturally-produced alpha-melanocyte stimulating hormone. The melanocyte-stimulating hormone is produced in a biological system and its main function is to stimulate melanogenesis.

When melanotan 1 is released from the organ of production, it initiates signaling cascades which stimulates the receptors on the plasma membrane of the target organ. The binding is important and it is often mediated by secondary messengers which include diacylglycerol, inositol phosphate, adenosine monophosphate and calcium ions. The complexity of the natural hormones varies in size, complexity and mode of binding from one receptor to another. It is essential that melanotan 1 be released on time for it to accentuate the required activity on the target organ.

Melanogenesis is an important process because it helps to prevent harmful ultraviolet rays from causing unprecedented cellular growth on the skin. The alpha-MSH activates a complex signaling cascade dealing with various receptors and it exerts its effect. Research on mice shows that the hormone has some effect on lipid metabolism and increase in appetite among other features. Melanotan I can induce sunless tanning and it is different from melanotan 2 because the latter is the second generation of the peptide. PT 141, melanotan 1 and melanotan 2 are under research for their potential benefits especially on skin.

Scientists then came up with the analog of melanotan 1 and enhanced its half-life through variousm biochemical reactions and it was referred to as melanotan and later melanotan 1. Recent studies indicate that the biosynthetic analog of the natural hormone is a thousand times more effective and more potent than the hormone produced by the body. Melanotan functions through triggering various signaling cascades and the activation of melanocortin receptors on melanin-producing cells or melanocytes.

Melanotan 2, on the other hand commonly called MT 2, MT-II or simply melanotan 2. It  is a synthetic peptide which is an analog of the naturally produced peptide alpha-melanocyte stimulating hormone . The main function of melanotan 2 is linked to the pituitary gland. The hypothalamus controls various functions such as development, growth, temperature and  metabolism, among other features. Research conducted on mice shows that an increase of melanotan II in the system increases pigmentation of skin or self-tanning and hair of the test organism.

Differences Between Melanotan 1 and Melanotan 2

Melanotan 1 and Melanotan 2
Melanotan 1 and Melanotan 2

The study on rodents and other test organisms show that the secretion of melanin usually occurs when the skin is exposed to UV rays. When UV rays hit the skin, it begins a signaling cascadewhich induces the formation of melanin from eumelanin. Melanin acts as a natural protector of the skin and in some cases, the production of the peptide is usually interfered due to  receptor failure or production inadequacy. Ultimately, when the pigment is converted to melanin, it traps the harmful rays, preventing any kind of uncontrolled cellular multiplication. Studies are still underway to determine the potency and efficacy of the peptide when compared to the natural hormone in the release of melanin. It is essential to note that melanotan 2 is very important in eliminating various types of skin cancer according to postulates.

The main difference between melanotan 1 and melanotan 2  is the latter’s ability to boost natural production of melanin on the skin. Studies have shown that melanotan 2 induces sexual behaviors on test subjects such as mice. When melanotan 2 is injected into mice, the male mice will solicit for females and erection is seen. When you buy tanning injections and inject into female mice, it reddens their sexual organs, lordosis and soliciting for males is increased. In addition, when melanotan 2 is administered, there is an increased consumption of food in both male and female mice. This indicates that the peptide works via the linkage of melanocortin receptors. Melanocortin receptor 3 and melanocortin receptor are the most affected and the efficacy of melanotan 2 can be monitored with probes.

Tanning

Tanning is an essential process that helps the skin avoid overexposure to the harmful ultraviolet rays of the sun. Research conducted on melanotan I and melanotan II revealed that the peptides are tanning injections and mice responded to the introduction of the two peptides by sunless tanning. However, this is for research purposes only. Both melanotan 1 and melanotan 2 are analogs of the alpha melanocyte-stimulating hormone. The difference between melanotan 1 and melanotan 2 is that the former is a full-strength straight peptide while melanotan 2 is a shortened version of the former. It is essential to note that when you buy melanotan , melanotan 2 has a better half life and its efficacy is improved as it can maneuver through tissues because of low molecular weight.

Melanotan 2 has libido-enhancing properties as seen in mice. It should not be used on humans. Spontaneous erections and solicitation behavior are seen in mice when melanotan 2 is injected. The amino acid sequence of melanotan 1 is longer than that of melanotan 2 because of the extra amino acids in the chain, so melanotan 2 tends to have a higher efficacy. Some features of melanotan 1 include appetite suppression, skin pigmentation and inhibition of the deposition of fats on the visceral and peripheral organs. Both peptides often vary in the activity level from one test subject to another. However, the efficacy and potency of melanotan 2 is seen to be better than that of melanotan 1 because of its low density and easy transferability across tissues. I think melanotan 2 is better than melanotan 1I because the active site has undergone further modification to enhance its ligand binding properties.