Melanotan 2 Lab Studies and Research/Conclusions
Melanotan 2 or what is commonly afamelanotide is a commercially synthesized analog of the naturally occurring alpha melanocyte-stimulating hormone. The peptide is a splice variation of the natural alpha-MSH, and it is essential in accentuating the release of the alpha-melanocyte stimulating hormone. The hormone is vital in accentuating sunless tanning or melanogenesis or the production of melanin from the epidermal layers of the skin. Melanotan 2 is the second generation of the alpha-melanocyte stimulating hormones. Researchers at the University of Arizona discovered Melanotan 1. The objective of the study was to find a natural hormone that can be used to alleviate the effects of skin cancer. Skin pigmentation is an important process because it helps in preventing the development of cancer cells on the skin. The peptide accentuates the release of the hormone and this, in turn, brings about a signal transduction, which induces the melanocortin receptors to release the hormone.
The alpha-MSH responds to the production of the hormone because it has selective receptors on the surface. The specific receptors are important in initiating the conversion of eumelanin to melanin on the skin surface and accentuate self tanning. Currently, there are a laboratory and research studies conducted on the peptide to determine the efficacy and potency of the peptide in accentuating various biological processes. Studies done on mice have shown that the peptide has a positive feedback mechanism on lipid metabolism, appetite, and libido. The lipolytic properties of the peptide have presented a new research phenomenon.
Since the peptide is small in nature and it can pass through cells and tissues easily to accentuate the desired action. The studies conducted are mainly geared towards the characteristics of the peptide in alleviating skin cancer or melanoma. The current peptide is an advanced version of the originally produced hormone and it more potent and efficient because the active region is short and it exerts its action easily. Research conducted is to identify a peptide that has a better half life and is more potent in eradicating skin related conditions.
Melanotan 2 and Melanogenesis
According to research conducted on mice and guinea pigs, melanin release is mainly caused by the exposure to ultraviolet rays. When the secretion takes place, the compound eumelanin is converted to melanin on the skin. The main function of melanogenesis is to protect the body from harmful rays. However, as research, shows there are subjects that do not release an adequate amount of the peptide or the receptors do not respond to the peptide released in the system. Typically, during tanning, the melanocytes on the epidermal layer of the skin undergo activation by the alpha-MSH and this triggers the production of more melanin and this causes the darkening of the skin. The production of melanin depends on the efficacy and the effectiveness of the melanocytes to respond to the peptide release. Melanotan 2 is a peptide that is still under study because it has the ability to induce sunless tanning. Research shows that the peptide can induce melanogenesis without exposing the skin to the sun. This is an important process because it will reduce the development of skin cancer.
The procedure conducted on mice indicates that the injection of melanotan 2 on the test subjects showed an increase in the production of the alpha melanocyte-stimulating hormone from the hypothalamus. This indicates that the peptide has the ability to activate the release of the hormone, moreover it has a better half life, and the potency of the modern peptide is better than the first generation. Over 50% of the peptide half-life is enhanced because of the introduction of the melanotan 2.
When buy tanning injections and inject to male and female mice, it shows an increase in sexual activity. The female mice showed signs of lordosis, reddening of the sexual organs, soliciting behaviors while the males showed erections and sought the females. However, it is important to note that the peptide is still under research and it has not been approved for any other use apart from research. Melanotan 2 is one of the most effective peptides in the release of the alpha melanocyte-stimulating hormone from the hypothalamus.
Melanotan 2 and the Hypothalamus
The primary function of melanotan 2 is to accentuate the pituitary gland, which is a small gland, located below the hypothalamus. The principle action of the gland is to secrete the hormone alpha melanocyte-stimulating hormone. The hypothalamus is very important to any animal because it regulates temperature, metabolism, development, and other essential components. Technical reports indicate that the peptide works in synergy to accentuate the release of the alpha melanocyte-stimulating hormone. The articulation is important because it determines the functionality of the hormone in accentuating melanogenesis. Research has shown that the melanotan peptides activate central melanocortin receptors and this is essential in triggering melanogenesis. Further research indicates that when the peptide is injected on the test organisms it does not have a significant effect on cholesterol and serum insulin in the system. Other research findings show that melanotan 2 is inhibited by messenger RNA, carnitine, and palmitoyltransferase 1.
Recommended Research Dosage
When you buy melanotan 2 for research, you will be able to understand the various aspects and functionality of the peptide. Since the peptide is an endogenous hormone and it is viewed as one of the best melanocyte-stimulating hormones because of the efficacy in producing the hormone. According to studies conducted, the peptide can cause several side effects. Some of the side effects include site reactions, nausea, and fatigue. This is seen on the test organisms and it is important that when you are conducting research you should maintain the dosage at a level that works well. Research studies have shown that when the tanning injection is used for an extended period of 1-14 days the desired pigmentation is achieved. The recommended research dosage is 2-3 milligrams depending on the research and the objective. It is imperative to not that there is a maximum limit that even when you increase the dosage of the peptide it does not cause any effect. The peptide is usually supplied as a white lyophilized powder and you should follow all the storage instructions to keep the peptide at optimal functionality.