Adipotide

Adipotide

$69.89

A peptidomimetic substance with a structural sequence of CKGGRAKDC-GG-D(KLAKLAK)2 that selectively acts and shrinks the adipose tissue fat supplying blood vessels and induce apoptosis.

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Product Description

Buy Pure Quality of Adipotide Peptide Online For Research Purposes

Adipotide is a peptide that plays a crucial role in promoting loss of fats in the peripheral and visceral organs. Peptidomimetics are a tiny protein-like chains which are manufactured to mimic the function of a peptide. Adipotide was developed in the United States as an alternative sequence to fight obesity. However, the peptide has not been used on humans. Studies indicated that the peptide-like the compound mechanism of action is through denaturing of fat cells or adipocytes.

Adipotide peptide promote loss of fats
Adipotide peptide promote loss of fats

This in turn causes a drastic decrease in the mass and volume of subcutaneous fat deposits. Adipotide destroys fat cells through a cascade of programs. First, it initiates a programmed cell death or apoptosis of the blood vessels supplying the fat cells. When the cells are deprived of nutrients, starvation begins and this causes cellular atrophy coupled with the accumulation of waste materials in fat cells. This is an irreversible injury which leads to the mitochondrial secretion of protease enzymes. The protease enzyme caspase is specific factors which are crucial in initiating cell death.

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transcription process
transcription process

The initiation of apoptosis prompts the activation of transcription process. This is where the DNA is utilized in creating mRNA and translation, a process where mRNA is used in creating a nascent peptide of genetic sequence which in turn promotes production of essential proteins that affect the process of cell death. Molecular research studies showed that adipotide process is only unique to 3D stereochemical conformation which allows it to bind to a couple of receptors, prohibitin and ANXA-2.

The receptors are found on the endothelial surface of blood vessels which supply white adipocytes. As the receptors are specific to the adaptive, an increased amount of adipocytes in the plasma will promote cell death and reduce weight. The formation of white adipocytes occurs when energy utilization is lower than energy consumption. This leads to surplus energy which is converted into fats and stored in the subcutaneous layer. Regular deposits leads to obesity.

Pathological research indicated that obesity is one of the main contributors to a wide array of diseases such as hypertension, cancer, endocrine disorders, cardiovascular diseases, degenerative diseases and other myocardial infarctions. In addition, an aberrant accumulation of white adipocytes predisposes an individual to lipomatosis and lipoma.

abdominal adiposity aggravate by increased level of white adipocytes deposit
abdominal adiposity aggravate by increased level of white adipocytes deposit

Studies showed that abdominal adiposity is aggravated by an increased level of white adipocytes deposit. Adiposity is only lipolytically active, therefore it requires a constant blood supply. Cutting the supply to fat cells will promote cell death as indicated earlier and therefore initiate fat burning or weight loss. The initiation of apoptosis plays an integral part in the excretion of white adipocytes which contribute to abdominal adiposity.

Adipotide has a higher affinity for the white adipocytes and its working principle is to cut blood supply to the active adipocytes. Moreover, adipotide binds to the blood vessel surface which nourishes fat cells. The synthetic peptide has a high potency in destroying fat cells. Prohibitin, also commonly referred to as PHB, is a protein which encoded by the PHB. The peptide works by inhibiting DNA synthesis and cell proliferation. A high amount of adipotide overcomes the effects of prohibitin since it is an antagonist.

Adipotide and Weight Loss

Adipotide and Weight Loss
Adipotide and Weight Loss

Studies indicated that the adipotide peptide is efficient in initiating weight loss. It is imperative to note that the peptide plays a crucial role in weight loss . Findings indicated that it is classified as a peptidomimetic and when injected into mice, it accentuates weight loss. The mechanism of action is by cutting the supply of food and nutrients to the adipocytes or fat cells.

Once the communication is cut, cells will die off because they do not get food. Adipotide is a peptidomimetic and it is made up of several amino acids in the chain that link to one another to form a complex molecule. When the peptide is injected into mice, findings showed that it decreases the overall body weight by up to 11%. . This shows the efficacy and potency of the peptide. The chains in the peptide simulate the natural production of hormones. Without this peptide, any weight loss is considered irrelevant.

Research on mice
Research on mice

During research, mice were injected with the adipotide peptide and monitored closely for any changes in body mass and deposition of fat cells in visceral and peripheral parts of the body. It is imperative to note that the peptide works by cutting the supply of blood and nutrients to fat cells. When this signaling cascade is activated, it tends to affect the overall functionality of the peptide. Once fat cells are killed, it results in overall reduction of subcutaneous fat cells.

A decrease in subcutaneous cells results in weight loss. Adipotide works efficiently because it kills fat cells progressively in a programmed fashion. This is essential because it triggers overall weight loss and the deprivation of nutrients and blood supply reduces production of more fat cells in the system. The program of targeted cellular death or apoptosis is essential because it reduces fat cells activity which will kill all fat cells in the peripheral and visceral organs.

Adipotide domains work in synergy
Adipotide domains work in synergy

Adipotide is made up of several domains and these domains work in synergy to enhance efficacy and potency of the peptide. It is essential to note that these domains work in synergy and independently as well to bring about weight loss. The first domain is referred to as the homing domain. This domain is crucial because it works by targeting membrane-associated protein. Membrane-associated protein is called prohibitin.

The homing domain works on the adipocytes endothelial cell matter and it results in weight loss because endothelial fat cells begin to shrink in size and die off. The second domain is membrane-disrupting domain. This causes cell death by inhibiting or stopping mitochondrial membrane activity within targeted cells.

When fat cells are deprived of nutrients and blood supply, they begin to die off. The experimental results are showing the possibility of utilizing the adipotide peptide in initiating weight loss. However, it is imperative to note that efficacy and potency of the peptide vary according to species and the environment.

Adipotide Dosage

Adipotide Dosage
Adipotide Dosage

Recent research studies showed that when adipotide is injected daily on the test subject, a significant weight loss is observed. The test subjects recorded a 20% decrease in stomach fat within four weeks.

This was a significant weight loss because it accounted for one fifth of the overall weight. However, it is imperative to note that some test subjects lost more weight while others lost a little weight. This varies because of other factors such as the environment, body condition and presence of leptin. Leptin is a peptide that signals satiety and when sensitivity to this peptide decreases or is affected, it results in obesity or weight gain.

Once leptin receptors are activated through administration of the hormone, it results in weight loss. Dead fat cells are metabolized in the body and this is very crucial because it enables the organism to lose weight. Once the adipotide peptide was administered, the test subjects were allowed a four-week recovery phase. The recovery phase is very important because it helps the test organism to adapt to changes in the biological system. Once the peptide is administered and the recovery phase observed, it would contribute to a long-term weight loss.

Postulated Benefits of Adipotide

Benefits of Adipotide
Benefits of Adipotide

The adipotide peptide is known for its potential benefits that it brings into play. It has been confirmed by the test subjects that it is very efficient in accentuating weight loss. Although the peptide in the market is solely for research purposes, the potential benefits look enticing. Adipotide features an enhanced mechanism of weight loss compared to other systems.

Since the peptide works by inhibiting the transfer of blood and nutrients to adipocytes, it is considered one of the safest peptides in accentuating weight loss in test subjects. Moreover, since the peptide triggers psychological symptoms, it does not affect or modulate the neurotransmitter matter.

This is important because it does not affect the neurotransmission systems. In addition, it does not have an amphetamine-type mechanism and this peptide can be administered with less gastrointestinal side effects. This is evidenced on the research mice. The mice experienced a significant weight loss and less gastrointestinal effects.

Potential Side Effects

Potential Side Effects
Potential Side Effects

It is important to understand that every peptide has its own merits and demerits and adipotide is no different. When the peptide was administered, the research mice displayed high energy levels. This increased the vitality of the mice and the treatment proved to be efficient in homeostasis. In addition, the research subjects showed no gastrointestinal discomfort and any kind of loss of appetite.

The therapeutic effect of adipotide is vital and it enhances weight loss while causing no significant changes in the system. The lack of adverse side effects of the peptide, compared to other peptides in the market, has created a buzz in the research industry because most scientists are looking for a peptide that has a higher efficiency while causing less or no side effects.

Moreover, the adipotide peptide caused minimization of lipids absorption in the gastrointestinal systems. Further findings indicated that the peptide has no effect on renal function and in cases where there is a significant renal function alteration, changing the dosage resulted in reverse of the side effects.

An important point to note is that there was no effect or kidney damage on the test organism.  Researchers adjusted the dosage administered to the mice and their renal functionality returned to optimal functionality. One of the main problems that were identified during the research was the presence of a lesion which could cause kidney failure if the problem was not dealt with immediately.

adipotide caused dehydration
adipotide caused dehydration

In some cases, adipotide caused dehydration because the mice increased water consumption. However, keeping these parameters at bay and modifying the various biological systems to function effectively will reduce the overall impact. Monitoring these parameters is important because dehydration could cause cellular damage and could trigger other health problems.

Adipotide and Muscle Mass

Studies done on mice showed that the adipotide peptide increases weight loss. This is crucial because it reduces excess fats in a biological system while increasing muscle cells. The findings showed that when the fat cells are shed off and the test animal subject is subjected to exercise, its muscle cells or myoblasts increase in number.

Adipotide and Muscle Mass
Adipotide and Muscle Mass

It is imperative to note that changes in the biological systems are results of the administration of the adipotide peptide. The superior fat burning ability is an essential concept and it will contribute to a faster muscle mass increase and optimal muscle recovery. Since the peptide is not classified as an anabolic steroid, it can accentuate the loss of excess fat cells while increasing myoblastic differentiation, development and maturity. The administration of the peptide coupled with high-intensity exercise for the mice showed that their muscle mass increased rapidly.

However, it should be noted that adipotide is solely for scientific and research purposes. It should not be used for human consumption. Planned studies on the peptide showed that the ability to accentuate weight loss plays an essential role in bringing in a new concept and that increases in muscle mass. As a researcher, when buying adipotide online or from any vendor, it is imperative that you check the certificate of analysis.

This is very crucial because it determines if the research findings can be used to benchmark other studies or not. The viability and purity of the peptide are crucial because some unscrupulous individuals lace a peptide with other additives such as mannitol. When a peptide is laced with other additives, results of the study will not tally or it cannot be reproduced in a similar scientific environment. This will affect the credibility of your findings.

Additional Information

Weight 0.005 g