CJC-1295.(DAC)

CJC-1295 (DAC)

$20.89

An injectable growth hormone peptide used to increase GH production by releasing hormone (GHRH) mimetic, or analog.

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Product Description

Buy CJC-1295 With Dac- Purchase Peptides from the USA

CJC 1295 without DAC, Mod GRF 1-29, modified GRF 1-29 or simply CJC 1295 is a peptide that consists of thirty amino acids in its chain. It is an essential peptide that accentuates the release of growth hormone and insulin growth factor 1. The modified version has a drug affinity complex or DAC. The drug affinity complex is essential because it enhances the binding affinity of the peptide to the ligand and prevents degradation of the peptide by foreign enzymes and other degradation compounds. The synthetic peptide has a half-life of about thirty minutes. Since it has a very short half-life, researchers are looking for avenues to use different modes of administration to maximize its activity and give the desired impact. Since its discovery, CJC 1295 has undergone various modifications that alter its structure and enhance its activity by increasing its stability. This was done by adding four amino acids to the structure. The part which stimulates the secretion of growth hormone from the anterior lobe of the pituitary gland is found in the first 1-29 amino acids so hence the name GRF 1-29.

The synthetic peptide has a half-life of about thirty minutes. Since it has a very short half-life, researchers are looking for avenues to use different modes of administration to maximize its activity and give the desired impact. Since its discovery, CJC 1295 has undergone various modifications that alter its structure and enhance its activity by increasing its stability. This was done by adding four amino acids to the structure. The part which stimulates the secretion of growth hormone from the anterior lobe of the pituitary gland is found in the first 1-29 amino acids so hence the name GRF 1-29.

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accentuating growth hormone from the pituitary gland
accentuating growth hormone from the pituitary gland

It is important to note that the original GRF 1-29 and modified GRF 1-29 have the same effect on the somatotrophic cells and the newer version is found to be more stable and effective in accentuating release of growth hormone from the pituitary gland.
The drug affinity complex is made up of the lysine molecule added to the original peptide chain. Lysine contributes to its complexity and a better half life. The original version CJC 1295 was difficult to produce and could not bring out the desired effect. Therefore, there is a need to find a peptide which can be modified to improve the production of growth hormone from the pituitary gland. CJC 1295 increases the production of the insulin-like growth factor 1. However, it is essential to note that it does not affect the levels of prolactin and cortisol in the system. Research showed that it works by enhancing bone density and production of myoblasts. When myoblasts differentiation occurs, more cells are produced which is important for growth and development. Moreover, CJC 1295 is known to induce lipolysis which is the breakdown of fat tissues and aids recovery. This is according to studies done on mice with reperfusion injuries and injured limbs.

rate of lipolysis
rate of lipolysis

CJC -19295 is a polypeptide that is made up of 30 amino acids. The polypeptide has amino acids substituted in four positions. The hormone is essential in accentuating the release of growth hormone from the pituitary gland. Growth hormone is an important peptide in cell differentiation, cell proliferation, development and maturity.
The release of growth hormone is alternating with somatostatin which is an antagonist of the growth hormone releasing hormone. When the level of CJC 1295 with DAC has increased the level of growth hormone, release increases. This is because the hormone reduces pulses of the antagonist. Studies revealed that the polypeptide is essential in increasing the rate of lipolysis while inhibiting formation of lipids and deposition of fats in the peripheral organs. In addition, the hormone is important in the production of Ghrelin, a hormone that is produced by the walls of the stomach and it is responsible for gastric motility and gastric emptying.

In addition, CJC 1295 works in synergy with GHRH or growth hormone releasing hormone to help in the release of growth hormone from the anterior lobe of the pituitary gland. The peptide is known to increase the sensitivity of receptors to the peptide and it helps in the increasing the GH per-somatotrope. Recent studies indicated that when CJC 1295 is mixed with growth hormone releasing hormone peptide 6, the production of growth hormone is increased while the levels of prolactin and insulin growth factor 1 remain unchanged.

CJC 1295 DAC is a more potent peptide than growth hormone secretagogues such as growth hormone releasing hormone peptide 2.

CJC 1295 DAC
CJC 1295 DAC

The main potency of the peptide can be attributed to the existence of the DAC or drug affinity complex. The drug affinity complex is known to increase the binding ability of  CJC 1295M<oreover, it presents the binding sites on the right avenue. In addition, the drug affinity acts as a cushion for protecting the peptide from degradation and enzymatic hydrolysis. MPA or maleimidoproprionic acid binds amino acid lysine to the DAC and this is one of the most reactive chemicals and it accentuates the activity of the molecule.

CJC 1295 and CJC 1295 with dac are the most important peptides in the release of growth hormone from the anterior lobe of the pituitary gland. However, the main difference between the two is the presence of the drug affinity complex. Modified growth factor 1-29 and Sermorelin have a half-life of 7 days and the peptide is more natural because it can induce the release of growth hormone in the most natural way. The changes in the peptide occur at the amino acid number 2, 8, 15, and 27 which includes D-ala, Gln, Ala, and leucine. It is the second version of the growth hormone releasing hormone.

Mechanism of Action of CJC 1295

Mechanism of Action of CJC 1295
Mechanism of Action of CJC 1295

Polypeptides are amino acids that are linked through amide bonds and they differ some are cyclic while others are linear. You may be asking yourself what is CJC 1295. However, it is important to understand the different protein structure types to get a better understanding of the peptide. There are four structural types. These include primary, secondary, tertiary and quaternary. The primary structure is the simplest of them all and consists of amino acids linked to each other in a linear manner. On the other hand, the secondary structures are folded sequence and are a simple form of the peptide.

Tertiary structure is a mild complex protein, which includes different amino acids that are folded, and it can be quite difficult to determine the origin of the peptide sequence. In most cases, it resembles interwoven wool with the last structure quaternary being the most complex structure of all. It includes tertiary structures linked together with numerous bonds. It is vital to understand that protein structures and conformation because it plays an important role in the efficacy, mode of action and effectiveness of the peptide. The structure of the protein determines the binding and the kind of ligand – it determines the kind of binding whether it will be strong or weak affinity.

What Makes CJC Without Different From CJC 1295 Dac?

CJC without DAC is a polypeptide that made up ofof 30 amino acids in its sequence of the larger family of the growth hormone releasing hormone family. Essentially, it is vital to understand that the peptide releases the pulses for a long time when compared to the natural hormone. The peptide has shown the ability to help injury recovery and other important benefits as well. CJC 1295 has a property to reduce fats in the body and according to studies on rodents. It has immune boosting properties making one of the most sought after peptide. It helps in increasing bone density and cellular repair to the skin. The peptide works in synergy with growth hormone releasing peptide in creating synergistic peptides and these can help in the production of growth hormone.

Although the peptide has the capacity to work on its own, it is essential to understand that running growth hormone releasing hormone alongside the peptide can help in increasing the activity of the growth hormone. There have been numerous researches on the functionality of the peptide in muscle building and the main research is to determine how the peptide is effective in accentuating the release of growth hormone as well improving muscle growth and muscle mass. The tetra-substituted version of the modified growth releasing factor 1-29 peptide or Sermorelin as it is popularly known is a more potent of the GHRH.

 different properties of the peptides
different properties of the peptides

The half-life of the original growth peptide releasing factor 1-29 is short and when you buy cjc-1295, you can be able to carry out different experiments and understand the different properties of the peptides. The peptide has been modified biologically to increase its activity as well as efficacy. Research indicates that the modification of the peptide increases its biological activity because it reduces the metabolic clearance rate while enhancing the activity. When the peptide has modified the potency and efficacy have the binding sites open for binding to the desired ligand.

Increasing the Potency and Efficacy of the Peptide

Increasing the Potency and Efficacy of the Peptide
Increasing the Potency and Efficacy of the Peptide

The addition of the drug affinity complex to the peptide is important because it gives CJC 1295 better bioavailability and it increases its efficacy as well as potency. The modification of the peptide has shown the ability to increase growth hormoneexponentially. When the peptide is combined with other growth hormone releasing hormone peptide, they function synergistically in activating the somatotropes to release the hormone from the anterior lobe of the pituitary gland. The half-life of the peptide is gradually extended and the affinity increases, as per research. The peptide can stay active for 7-10 days after addition of the drug affinity complex. The drug affinity complex allows the peptide to run across the body without undergoing any kind of degradation, therefore, delivering the optimal result. The drug affinity complex can take days looking for the receptors to bind.

Dosage

Dosage
Dosage

The naming of the peptide can be quite confusing to some people but it is important that you understand that the best peptide outside is the growth hormone releasing hormone. CJC 1295 is the best peptide and it is important that you have all the information readily available before purchasing any vial in the market. Just like all peptides that are touted in the market, CJC 1295 is sold in a lyophilized vial and this vial should be kept in a cool dry place away from sunlight. In addition, when reconstituting the vial, the process should be done with sodium chloride or bacteriostatic water.

The peptide mimics the natural release of the growth hormone and the most recommended dosage is 100mcg to 200 mcg per day. It is important to note that combining CJC DAC1295 with other peptides can help in increasing the amount of growth hormone released. It is important to note that the peptide is administered in micrograms and not milligrams as it is usually done with other peptides. The peptide works on the anterior lobe of the pituitary gland to accentuate the release of growth hormone.

The use of growth hormone in treating various conditions is still under research because all these peptides have to undergo a thorough scrutiny and testing before they are approved for consumption. Findings from the studies indicated that CJC 1295 can be used in treating children with impaired growth, the peptide mimics the natural body mechanism, and a. According to studies done on guinea pigs and rodents, the peptide mimics the natural mechanism. The recombinant technology used in the production of the peptide ensures that only clean Cjc 1295 with DAC is produced and the quality is impeccable. In adults, the production of growth hormone reduces gradually when they begin aging. In most cases, the main cause is Failure of the receptors to recognize the hormone. In some cases, and it is the failure of the somatotropes to produce the required amounts of the peptide.

 Cjc 1295 with DAC
Cjc 1295 with DAC

The recombinant technology used in the production of the peptide ensures that only clean Cjc 1295 with DAC is produced and the quality is impeccable. In adults, the production of growth hormone reduces gradually when they begin aging. In most cases, the main cause is Failure of the receptors to recognize the hormone. In some cases, and it is the failure of the somatotropes to produce the required amounts of the peptide.

Recent studies indicate that the peptide can be used in accentuating the release of the hormone in the future although these are tantamount to approval from the relevant scientific bodies such as food and drug administration among others. Currently, all the peptides supplied in the market are for research purposes only and you should get a peptide that has a certified purity and quality level. This is important because you cannot use low-quality CJC 1295 to benchmark further studies.
The neurosecretory cells and dysfunction can be treated with the peptide if the current research it is anything to go by. All the peptides are still under research. Until they are safe for use in human beings, you can only buy CJC-1295 for research purposes only.

Additional Information

Weight 0.005 g