GHRP-2

GHRP-2

$20.89

GHRP-2 is a synthetic agonist of ghrelin – a gut peptide which binds to the growth hormone (GH) secretagogue receptor.

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Purchase GHRP-2 Online- What is GHRP-2 Peptide?

GHRP-2 Peptide
GHRP-2 Peptide

Growth hormone releasing peptides is a small category of amino acids that are known to accentuate the release the growth hormone through induction of the pituitary gland and hypothalamus. The process occurs through the activation of several G-coupled proteins. It is imperative to understand that the hormone plays an important role in growth and development. Growth and development would be different if the hormone is not produced from the anterior lobe of the pituitary gland. The hormone was discovered in the 1990s and was synthesized as a metenkephalin derived polypeptide.

KP 102 or GHRP-2 as it is widely known, does not have any kind of homology with the between GHRH. The hormone has 6 amino acids in its sequence and they are connected through amide bonds. GHRP-2 exerts its functionality on the anterior lobe of the pituitary gland and this is important in accentuating the production and release of GHRP-2 from the somatotropes. In addition, the peptide has a slight stimulation to the levels of cortisol, prolactin and adrenocorticotropic hormone. GHRP-2 is considered as one of the most effective growth hormone secretagogues and it has the highest potency of accentuating the release of growth hormones.

Growth and development would be different if the hormone is not produced from the anterior lobe of the pituitary gland. The hormone was discovered in the 1990s and was synthesized as a metenkephalin derived polypeptide. KP 102 or GHRP-2 as it is widely known, does not have any kind of homology with the between GHRH. The hormone has 6 amino acids in its sequence and they are connected through amide bonds. GHRP-2 exerts its functionality on the anterior lobe of the pituitary gland and this is important in accentuating the production and release of GHRP-2 from the somatotropes.

In addition, the peptide has a slight stimulation to the levels of cortisol, prolactin and adrenocorticotropic hormone. GHRP-2 is considered as one of the most effective growth hormone secretagogues and it has the highest potency of accentuating the release of growth hormones.

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GHRP-2 has numerous beneficial properties
GHRP-2 has numerous beneficial properties

Recent findings indicated that GHRP-2 has numerous beneficial properties. These include promotion of a lean body, reduction of adiposity. Moreover, it has shown to have no lipogenic properties. Consequent research indicated that GHRP-2 does not have any kind of relation with other hormones such as Sermorelin and CJC 1295. However, all these hormones are important in the production and secretion of growth hormone. GHRP-2 interacts with ghrelin, a hormone known to bring about an increased hormonal release of the growth hormone through synergy and diminishing of the activity of somatostatin.

Somatostatin release occurs in tandem with the production of the growth hormone in pulses. The reduction of somatostatin activity means that the activities of ghrelin and GHRP-2 are increased gradually. Growth hormone releasing peptide 2 is a synthetic peptide that is produced as an analog of the GHRP-6 and it has the same effect on the secretion of the growth hormone. In addition, it has mild or no effect on the levels of PRL, ACTH and cortisol.

When the growth hormone release is induced by GHRP-2, the natural response of the system is to increase the level of calcium in the system. This increases the levels of ghrelin as well. GHRP-2 is a more potent and effective growth peptide than GHRP-6 and it has the ability to produce growth hormone at a steady pace for a long time without alteration.

cells of somatostatin release GHRP-2 from the anterior lobe of the pituitary gland
cells of somatostatin release GHRP-2 from the anterior lobe of the pituitary gland

Moreover, the peptide has shown to have an increased half-life than any other growth hormone releasing peptide. Laboratory studies showed that GHRP-2 increases the level of IGF-1, the peptide which induces the production of growth hormone, and it increases its capacity compared to other peptides. The cells of somatostatin release GHRP-2 from the anterior lobe of the pituitary gland, the high level of analogs lowers the amplitude per cell of the somatostatin released to the system. Unlike ghrelin, GHRP-2 does not promote lipogenesis on the peripheral and visceral organs and does not have any effect in increasing gastric emptying and appetite.

Ghrelin is a hormone that is produced by the walls of the stomach, the peptide plays an important role in inducing a feeling of hunge and it has positive feedback on gastric emptying and gastric motility. In a physiological system, the activity of the growth releasing factors are inhibited at the receptor level. Studies showed that the intake of growth hormones is mediated by NPY/ Agouti gene and neurons in the arcuate region.

Characteristics of GHRP-2

According to recent studies done on rodents, the main function of  GHRP-2 is to induce and boost the production and secretion of the growth hormone gene. This is the main activity of the pea-sized gland found at the base of the brain. The pituitary gland is important for promoting several functions that are important in the operation of the biological system. Some of these functions include growth, temperature regulation, pain relief, blood pressure and homeostasis. GHRP-2 is important in promoting the increase in the secretion of somatotrophic cells and these are important in the growth and promotion of protein synthesis.

secretion of somatotrophic cells
secretion of somatotrophic cells

The increase in the activity of the peptide is increased by the blockage of antagonist somatostatin activity. GHRP-2 is responsible for regulation of the endocrine system and it affects cells proliferation, neurotransmission through G-coupled protein receptors.

Further studies on GHRP-2 have shown that when you buy it, you are able to try out its different properties and understand how it works. The peptide has shown the ability to increase the production of insulin-like growth factor 1 which is popularly known as somatomedin C. The protein is produced in the liver and is an endocrine-related secretion which iis important in the repair of cells and muscle tissues. In addition, GHRP-2 increases the influx of ca2+, therefore enhancing growth and development.

GHRP-2 and Appetite

It is imperative to understand that GHRP-2 does not induce hunger by itself but rather induces the production of ghrelin, a hormone known to accentuate gastric motility, gastric emptying and a feeling of hunger. GHRP-2 is composed of 28 amino acids and is produced by epsilon cells in the pancreases and the stomach cells. The peptide has shown the ability to boost the functionality of the growth hormone. When the amount of ghrelin is increased in the system, there is a rapid feeling of hunger. According to research conducted on mice, there is an increased food intake once the mice were administered with GHRP-2. An increase in food intake initiated a compensation elevated function and this will in turn,will bring about homeostasis and increase protein synthesis.

Effects of GHRP-2 on Biological Systems

Effects of GHRP-2 on Biological Systems
Effects of GHRP-2 on Biological Systems

Research studies revealed that GHRP-2 has several advantages. As per research done on mice, postulated benefits include the breakdown of body fat into energy. Therefore, lean body mass lower cholesterol levels and there is an increase in body mass. Improvment in bone density, increased ability to repair tissues and enhanced body defense are some of the other benefits of GHRP-2. On the contrary, there are numerous anticipated side effects as well. According to the study, there was increased water retention, increased fatigue, reduced insulin sensitivity and the development of carpal tunnel type of symptoms.

Ghrelin production is increased by the activation of GHRP-2. It is an endocrine hormone which plays an important role in homeostasis and energy regulation. Research findings showed that an increase in the level of ghrelin is important in burning fat and food intake. The increase in the level of ghrelin has shown the ability to reduce obesity and increase anorexia. The synthetic version of the peptide has an enhanced bioavailability and there is evidence of increased potency compared to its predecessor.

Research on GHRPH-2

Recent studies revealed that the rodents displayed increased food consumption and body weight. GHRP-2 plays a crucial role in accentuating the release of ghrelin. There is enough data to prove that the peripheral administration of the peptide promotes lean muscle protein and increases food intake and in most cases, muscle development is possible. GHRP-2 enhances the production of growth hormone from the somatotropes on the anterior lobe of the pituitary gland. Hormonal regulation of food intake can be divided into long term and short term fat storage signals which include leptin and insulin, the short term include Ghrelin ,cholecystokinin , and PYY. Ghrelin is a peptide that is secreted on the walls of the stomach and it acts on the NPY-AGRP neurons, and it activates in the arcuate nucleus.

 peptide and ghrelin
peptide and ghrelin

One of the most important aspects to consider in peptide research is an ongoing process and the mechanism of how the hormones circulate and how they reach the hypothalamic neurons is still unclear. The research on rodents indicated that centrally administered ghrelin acts on the growth hormone secretagogues and this stimulates food intake. There is evidence that it has spontaneous variation in the endogenous amounts of ghrelin and this may play a role in diurnal meal times. In addition, postprandial suppression of the ghrelin hormone is equal to the size of the meal taken.

Scientific data indicated that the peptide and ghrelin can elicit anorexic properties and can cause an acute change in food taken in humans. Although the conclusion of GHRP-2 activity has not been seen more results are indicating the possibility of having the same. The alteration of ghrelin has a huge magnitude on the kind of downstream effects it occurs through nervous and peripheral receptors. Studies revealed that the peptide may be used in the future to treat various conditions. However, it is important to note that research is still ongoing and the peptides have not been approved for human consumption. All the peptides are for research purposes only.

GHRP 2 Mode of Administration

Growth hormone releasing hormone is an essential peptide in promoting cellular division, development, and maturity. This process is important for the growth of bones and the regeneration of damaged or dead cells. Research on mice showed that when GHRP 2 is administered, its efficacy and potency is largely reduced because the liver breaks down all the compounds in the peptide.

In most cases, researchers are using subcutaneous injections and oral mucosal delivery as an avenue to administer GHRP 2. The submucosal method is the most effective because the peptide is delivered in its active concentration. The mucosa membrane is a thin layer and it is highly vascularised, hence the peptide will enter the systemic circulation quickly unlike other modes of administration. For some peptides, other techniques of administration can work. However in most cases, this does not work because of the degradation of enzymes and other compounds in the system.

GHRP-2 and CJC 1295 blend

growth hormone levels
growth hormone levels

The shortened peptide is a bioactive portion of the growth hormone releasing peptides mimics the activity of the growth hormone releasing peptides by stimulating the anterior lobe of the pituitary gland to secrete growth hormone. Sermorelin has shown enhanced effectiveness in increases the GH pulses while inhibiting the activity of somatostatin. Both ghrelin and the growth hormone releasing peptides (GHRPs) were created upon discovery in the early 1980s. This mostly led to the generation of the first secretagogue GHRP-2. CJC 1295 and GHRP-2 are closely related because of their action of activating ghrelin. Ghrelin increases energy consumption, gastric emptying, and feeling of hunger. This has a positive feedback mechanism in stimulating the release of growth hormone from the anterior lobe of pituitary gland. A combined vial of the peptide has shown increased potency and effectiveness.

GHRP-2
GHRP-2

This mostly led to the generation of the first secretagogue GHRP-2. CJC 1295 and GHRP-2 are closely related because of their action of activating ghrelin. Ghrelin increases energy consumption, gastric emptying, and feeling of hunger. This has a positive feedback mechanism in stimulating the release of growth hormone from the anterior lobe of pituitary gland. A combined vial of the peptide has shown increased potency and effectiveness. GHRP-2 and CJC 1295 are capable of stimulating and creating a larger pulse on the GHRH with a consistency and predictability to maintain hormone level at an optimal level.

Studies revealed that growth hormone has lipolysis process while inhibiting lipogenic activities which is the deposition of fats in the peripheral and visceral organs. Synergistic functions of CJC 1295 and GHRP-2 help in enhancing the release of growth hormone per cell.

The functioning of one peptide cannot be effective as required. However, scientists are looking for ways to blend different peptides to increase the potency and effectiveness of the polypeptide. A blend of CJC 1295 and GHRP-2 is effective in increasing the output of growth hormone from the pituitary gland.

Although GHRP-2 is not related to any other GHRH, the action is usually centered on specific receptors that are located on the pituitary gland. The interaction with ghrelin is known to have slight stimulatory effects on the level of cortisol, PRL and ACTH levels in the body. There is an influx of calcium ions in the physiologic system when the combined hormones are sensed by the cells. The cells then stimulate the pituitary gland to release the hormone.

Additional Information

Weight 0.005 g