GRF 1-44


A growth hormone releasing factor, GRF (1-44), also known as somatocrinin is a potent growth hormone releasing factor secreted by the pituitary gland.

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Buy GRF 1-44 Research Peptide Online  – About What is GRF 1-44

GRF 1-44

GRF 1-44 is  a splice variation of the naturally produced growth hormone releasing hormone. The growth hormone releasing hormone is essential in accentuating the production and release of the growth hormone from the anterior lobe of the pituitary gland. The growth hormone is released in pulses alongside somatostatin and pulsation depends on the receptors and binding of molecules.

The hormone is usually produced during the gestation period on week 18-29. When the hormone appears on the hypothalamus, that is the initial period of production and is often seen in the fetus during this period. Recent studies showed that for most animal species, somatoliberin or GRF 1-44 is very important in accentuating the synthesis and secretion of human growth hormone from somatotrophic cells.

In addition, recent studies also showed that somatocrinin is also synthesized in the neurons which are located in the arcuate nucleus of the hypothalamus. The hormone is then transported to the area of interest where it exerts its function.

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Researchers are still investigating the benefits of the GFR 1-44 peptide especially when it comes to its potency and efficacy. Studies indicated that the synthetic peptide has a short half-life compared to the endogenously produced hormone. Moreover, its half-life lasts for several seconds to minutes.


Therefore, the perfect method should be in place to administer GRF 1-44 in the right dosage and to bring about desired effects on the test animal. Contrary to other exogenous peptides which are synthesized commercially, GRF 1-44 has undergone a wide array of modifications such as chemical reactions and modifications geared towards increasing its half-life and functionality.

Moreover, these modifications are important because they also improve the bioavailability of the peptide for research. In addition, the binding sites of the peptide are placed strategically to allow for effective binding of the substrate. In any biological system, the binding of the ligand to the receptor is an essential component. Since the GRF 1-44 peptide is modified, it increases its affinity and results in a stronger binding.

The synthetic peptide is able to travel long distances in a biological system without affecting its potency and efficacy. This is important because one common problem of the endogenous peptide is that the enzymes and other components in the system will cause loss of activity, denaturation and degradation.

GRF 1-44 is crucial in accentuating release of growth hormone from the somatotrophs because it increases efficacy and production of the GRF 1-44 peptide in a pulsatile fashion. Recent research studies showed that GHRH has an essential role in promoting slow wave sleep.

GRF 1-44 and Sleep


The growth hormone releasing hormone is present in subtle amounts in the blood stream in the plasma. Brain concentration indicates a variation in times. There have been studies which indicated that there is a correlation between GHRH concentration and circadian rhythm in human beings.

The concentration is low in the morning and gradually peaks in the evening or at night. The elevation of endogenous levels of GHRH has been shown to induce slow-wave sleep and rapid eye movement with little or no impact on body temperature. Plasma concentration of the growth hormone releasing hormone is influenced by induction of sleep mode.

Some studies revealed that the GRF 1-44 will provide a new frontier into the understanding of how patients with Cushing’s syndrome can use it to induce slow-wave sleep. However, it is imperative to note that the peptides are still under research and they have not been approved for human consumption. One of the main features of GHRH is that it can cross the blood-brain barrier. Therefore, it can be readily absorbed into the gut with no enzymatic degradation and immediately exert its effect on the brain.

studies on GRF 1-44
studies on GRF 1-44

In a biological system, the presence of GHRH is available in relatively high concentration and efficacy of the peptide in accentuating sleep cannot be underestimated. According to radioimmunology assay, the half-life of GRF 1-44 in human plasma is between 7-9 minutes.In instances where the peptide interacts with other drugs, they may inhibit themselves or other peptides therefore metabolized by peptidases. Internal mechanisms,which control sleep have fascinated scientists for a very long time. There are many endogenous compounds that have shown the ability to control sleep. Some of these peptides include CCK or cholecystokinin and prostaglandin, among others.

Most humoral mediators have some relationship in making a person fall asleep and affect circadian rhythms in one way or another. Since the discovery of GHRH, there have been numerous postulations on the whether humans can be subject to pressure to sleep by the use of the GRF 1-44  peptide.However, the hormone is for research purposes only and is not approved for human consumption.

Growth hormone releasing hormone has been described as a sleep promoting substance. It is not classified as a sedative. The modulator effect it has on wake and sleep functions is still under study to give a comprehensive result on the same.According to research, subjecting mice to GHRH let them sleep for a longer duration than expected. Even after being disturbed, they got back to sleep with their sleep pattern was unaltered. There are subsequent studies that geared towards improving the peptide rather using it because of its short half-life and enzymatic degradation.

Once the peptide has been approved for use, it may present an ultimate cure for insomnia and other conditions. However, it is important to note that the peptides supplied are  exclusively for research purposes only.

GRF 1-44 and Neurotransmission


Growth hormone releasing hormone is known to induce growth of cells from nascent and mature cells. It is important to note that the GRF 1-44  peptide can accentuate production of cells to heal emaciated or damaged cells in a biological system.When the hormone level rises in blood, it elevates the levels of cyclic adenosine monophosphate. This in turn activates protein kinase A and allows the cyclic adenosine monophosphate response element binding protein or what is called CREB to under an addition of phosphate group.

The addition of a phosphate to the chain is essential in signaling transcription factors and other components via the binding of CREs to the cyclic adenosine monophosphate on the promoter side of the gene sequence. On the other hand, production of the hormone via that phospholipase C pathway is crucial in cellular differentiation, development and maturity.

The main target in this context is the activation of PLC or phospholipase pathway through several β G-proteins. The activated phospholipase C pathway stimulates production of calcium ions in the endoplasmic reticulum and fusion of triphosphate leads to production of the hormone.Channels that release growth hormone are calcium ion-dependent and when calcium levels in the serum increase, hormonal production is enhanced.

peptide is essential in accentuating release of growth hormone
peptide is essential in accentuating release of growth hormone

The growth hormone releasing hormone is essential in stimulating the release of growth hormone from the somatotrophs in the anterior lobe of the pituitary gland. GHRH is the classic postulated hypothalamic hormone under investigation for potential benefits.The discovery and characterization of the peptide cannot be underestimated especially in modern science. The peptide is essential in accentuating release of growth hormone from the somatotrophs in the anterior lobe of the pituitary gland.

A reduction in the production of growth hormone or failure of the receptors to respond to the peptide release is a causative agent for poor or stunted growth. Identification of the peptide is essential in understanding aspects of the growth hormone releasing hormone and the etiology of it’s deficiency.Other aspects include receptor failure to accentuate production and the efficacy of the peptide.

GRF 1-44 and GH deficiency


Currently, there are various studies geared towards identifying functionality and efficacy of the grf 1-44 peptide in accentuating growth and development. The use of the peptide in treating mice with low secretion of growth hormone.

Endogenous production of the peptide is crucial in bringing about a new concept in modern science and research. Research showed that the injection of GRF 1-44 to the test mice showed a linear growth unlike another concept of the studies. It is essential to note that the peptide is vital in accentuating release and transportation of the peptide to the organ of interest.

Growth hormone plays an essential role in the production of new cells, development and their maturity in a biological system. Therefore, the peptide will improve its efficacy, wound healing and tissue repair in most organisms. The growth hormone releasing hormone is essential understanding various biological properties and the clinical use of the peptide for research and development.

Release of the growth hormone from the pituitary gland is regulated by two hormones: the growth hormone releasing hormone accentuates its release while somatostatin inhibits its release from cells.

Growth hormone releasing hormone is released in pulses or episodically in bursts which can be detected by using various measurement and concentration monitors. In addition, the presence of the peptide has shown to be efficient in identifying ectopic tumors.

This is a positive move in the scientific world. The sampling of blood in test subjects after 20 minutes, five hours and 24 hours can help determine the total secretion and variation in release of the peptide. Identification of the secretory profiles and amount of the peptide released into serum in any biological system plays a crucial role in improving the subject’s activity towards production of better human growth factors, among others.

Studies on male and female mice indicated that the secretion of the growth hormone mostly occurred at night. The explanation is that the cells are repaired at night and new cellular regeneration occurs at this time. Interaction of the hormone and modulators of growth hormone are essential in bringing about a net positive effect on growth and development.

Identification of the Most Active Site

According to research on the full biological activity of the growth hormone, releasing hormone released from tumors showed that residues in 29 amino acids are crucial in bringing about a new change. Stimulatory effect of the growth hormone releasing hormone on growth hormone occurs via stimulation of cyclic AMP production.


Identification of the Most Active Site
Identification of the Most Active Site


Isolation of the messenger RNA from both tumors enabled scientists to isolate the cells and come up with a working platform of using the GRF 1-44 peptide to accentuate various functionalities in cells. The sequenced human genes showed that the growth hormone releasing hormone is located at chromosome 20  and this is determined that it spans at 10-kilo base pairs and contains five exons.

Sequence of the growth hormone releasing a hormone in mice consists of 43 amino acids and differs from human growth hormone because it has fifteen amino acids deleted. Studies indicated that the hypothalamic nucleus has various neurons and it is vital in accentuating the release of GH.

The radioimmunoassayable of growth hormone releasing the hormone in the serum of mice showed that the detection increased 100-1000 fold when the GRF 1-44 peptide is administered externally. It is important to note that the peptide can be used in treating acromegaly in mice as per recent studies.

peptide can be used in treating acromegaly
peptide can be used in treating acromegaly

When GHRH is administered on the test organism, it exhibited a net positive effect in generation of new cells and promotion of growth hormone activities. It is vital to note that the effect of GHRH on the GH secretion is dose- dependent and you should administer low doses first before moving to a higher dosage to avoid over-secretion or production of numerous cells without control on multiplication.

When the peptide was administered continually, it caused an increased secretion of the growth hormone and follicle-stimulating hormone. Researchers used various immunoassay techniques to identify the concentration of these hormones.

Additional Information

Weight 0.005 g