Buy Hexarelin Research Peptide Online – Hexarelin Peptide Sciences
Hexarelin acetate or hexarelin is a commercially synthesized six amino acid peptide that is classified under the growth releasing hormone peptides mainly because of its functionality of stimulating the secretion of growth hormone from the anterior lobe of the pituitary gland. The stimulation by the polypeptide does not affect the natural production of the peptide. The structure and conformation of hexarelin is similar to that of growth hormone hexapeptide or GHRP-6. However, the peptide does not have any effect on the level of Ghrelin. Ghrelin is a hormone that is known to accentuate gastric emptying and gastric motility. Hexarelin is a synthetic secretagogue of the peptide and it is composed of six amino acids on its polypeptide sequence. The peptide is one of the strongest peptide in the market and is the most dynamic growth hormone releasing synthetic hormone. Recent research showed that the peptide has the ability to reduce deposition of fats to the peripheral and visceral organs. Just like its counterparts, hexarelin is effective when administered synergistically with other peptides such Sermorelin, GRF and GHRH.
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The circulation of GH can be increased by the use of synthetic peptides such as hexarelin. It has other benefits apart from increasing the level of growth hormone. The peptide has been known to promote lipolysis and it is vital in increasing the levels of insulin-like growth factor 1 or IGF-1 in the liver. Insulin-like growth factor 1 is vital in accentuating release of the growth hormone peptide. Hexarelin has a molecular mass of 0.887-kilo Daltons and there are chances that the peptide can be used to alleviate excess body fat. The effectiveness of the peptide is seen within 30 minutes of administration and the half-life varies from 30-45 minutes depending on the test subject. The most important aspect in this category is the rapid secretion of growth hormone. Hexarelin is essential in helping the development of kids into adults. The peptide is a synthetic hormone and it activates the growth hormone secretagogue receptor or the GHSR, and it is similar to Ghrelin.
Recent studies revealed that the peripheral distribution of the growth hormone releasing secretagogue in serum and heart vessels show that hexarelin may have a positive effect on the secretion of the hexarelin. The peptide has hormonal inducing properties and neuroendocrine effects as well. In addition, the non-GHSR CD 36 has the ability to induce certain receptors which are specific to the cardiac region. When compared to other peptides such as GHRP-6 and Ghrelin, hexarelin has a higher potency and enhanced effectiveness and it is a promising therapeutic agent for most cardiovascular conditions.
GHS or growth hormone secretagogue is a class of small synthetic peptides that are known to stimulate production and release of the growth hormone from the somatotropes on the anterior lobe of the pituitary gland. The peptide works via the binding of the growth hormone receptor 1a or GHSR 1 a. Moreover, the GHSR 1 a is a G-protein coupled receptor that was identified to have a positive function on the pituitary. It was later discovered that it has an endogenous hormone or receptor Ghrelin. The peripheral distribution of the GHSR 1a in the prostate, bone, hat, fat, adrenals and digestive system has supported the physiological roles of Ghrelin and the release of the growth hormone into the system. For Ghrelin and the growth hormone releasing secretagogues, reports indicated that they participate in several orexigenic properties especially in fat metabolism, immune, cardiovascular among other areas stipulated by the peptide.
Hexarelin and Cardiac Functionalities
Studies that were done in the past decade showed that the administration of Ghrelin is essential to accentuating cardiac functionality. This was proven through the administration of the peptide to mice and guinea pigs with left ventricle ejection infarction. In the rodents, the myocardial infarction or simply MI, Ghrelin administration reduced their mortality rate and it helped in the prevention of malignant arrhythmias and improved the left ventricle dysfunction as well attenuation of the cardiac remodeling of the subacute phase.
However, Ghrelin is unstable. Therefore its half-life, potency and the effectiveness is slightly hampered. Growth hormone secretagogue hexarelin is a biochemically stable compound. It is a more potent hexapeptide that can be administered orally to test subjects as an alternative to the Ghrelin. It exerts its effects longer and more effectively than the original peptide. Moreover, hexarelin uses GHSR 1 a receptor just like the natural biological system, thereby its effects is beneficial and long lasting. The cardiac functionality of hexarelin is mediated by the receptors and the activation of the CD 36 receptors.
Hexarelin and Apoptosis
According to research carried out by scientists, neonatal rats cardiomyocytes were subjected to hexarelin dosage. The levels of angiotensin II ere reduced and this accentuated DNA fragmentation and apoptosis of the myocytes. In addition, the viability of the cardiomyocytes improved greatly and this helped in the reduction of cell death. Hexarelin treatment has shown the ability to inhibit the effects of doxorubicin -induced apoptosis.
The peptides promoted the survival of H9C2 cardiomyocytes and endothelial cells. The cardioprotective effects of hexarelin can be seen in the endothelial cells and the anti-apoptotic features of the peptide can be seen as well. It is imperative to understand that the administration of hexarelinon test subjects alleviated left ventricle dysfunction and cardiac cachexia. In rats with congestive heart failure, the peptide suppressed the activation of cardiomyocytes apoptosis and stress.
Hexarelin and Cardio-Protective Effects
Hexarelin is one of the most studied ghrelin mimetics and is one of the latest potent growth hormone releasing compounds. The peptide is seen to have an effect on prolactin and cortisol release. Hexarelin is more potent in the production of growth hormone from the pituitary gland. The effect of prolactin and cortisol release depends on the concentration of the hormone in a biological system. All the ghrelin mimetic have unique properties that bring about the release of growth hormone from the pituitary gland.
It is imperative to note that the growth hormone is released alongside somatostatin from the somatotrophs and when the production of somatostatin is at its peak, the production of the growth hormone is at its lowest. Studies revealed that hexarelin reduces the extent of cerebral cortex injury and hippocampus after a hypoxia-ischemia. This was a study conducted on neonatal rats. The study showed that ghrelin may have a role in this as well.
All the ghrelin mimetic or growth hormone releasing peptide have a potential antioxidant benefit on the activation of the GHS-R type 1a cells present in the Leydig and Sertoli cells. This is important because the action has an antioxidant and anti-inflammatory effect on cardiac cells. This is achieved through enhancement of the three main antioxidant systems in the body which include catalase, glutathione peroxidase and superoxidate dismutase. The system is essential because it helps in the alleviation of free radicals present in the system and this improves the health of the cardiac cells.
Research showed that the peptide has cardioprotective effects and the GHS-R messenger RNA is expressed in the cardiomyocytes or the cells of the heart when hexarelin was administered. This showed that hexarelin abates the cells of the heart from ANG-2 induced cell death. This is via the inhibition of the caspase-3 activity and the expression of Bax through an increase of Bcl-2 which is usually reduced by the presence of ANG 2
In a different study, research showed hexarelin may have potential benefit in treating atherosclerosis and this is the most important aspect in preventing the death of cardiomyocytes. The peptide suppressed the formation of atherosclerotic plaques in neonatal mice and it reduced the HDL-c to LDL ratio by increasing the level of nitrogen oxide and aortic messenger RNA of the CD36 and eNOS. Moreover, research showed that the peptide improved the smooth muscle cell and calcium sedimentation on the wall of the aorta. From cell formation induced by high levels of ox-LDL is largely reduced when the peptide was administered. In summary, the expression of a high lipid diet can be regulated by the use of the HDL-c/LD-c ratio and this aids in an increase of NO and the prevention of cardiomyocytes death.
Effects of Hexarelin on Ischemia Reperfusion Injury
The hearts of neonatal mice were subjected to a half an hour then two-hour reperfusion. Hexarelin was seen to reduce the size of the infarction and this was determined by triphenyltrazolium chloride staining. The peptide provided protection and reduced the activity of protein kinase C inhibitor chelerythrine. The treatment of the peptide was seen to inhibit cardiomyocytes apoptosis. It preserved the electrical properties of the cells and promoted cellular survival through the modification of the nitrogen activated protein kinase pathways. In addition, hexarelin induced a positive inotropic effect on ischemic cardiomyocytes.
As per the research findings, the rats were treated with hexarelin on the left ventricle and the pressure build up showed that the cells were not damaged as opposed to when left to naturally heal. The administration of the peptide protected the heart vessels and it had a positive effect on postischemic ventricular dysfunction as well as hyperactive responses of coronary angiotensin II.
Hexarelin and Cardiac Fibrosis
Hexarelin administration on hypertensive and spontaneous mice for 40 days showed a major reduction in cardiac fibrosis. This was seen through the reduction of myocardial collagen deposition and the interstitial collagen thereby reducing myocardial hydroxyproline and reducing the levels of collagen I and III, messenger RNA and the expression of the proteins. In addition, hexarelin administration was seen to increase the concentration and level of metalloproteinase -2 and -9 activities and reduced the myocardial messenger ribonucleic acid expression on the tissue. The treatment of cultured fibroblasts with hexarelin was seen to inhibit the activities of angiotensin II proliferation, transformation of transforming factor-beta induced DNA synthesis, collagen synthesis and reduction in the levels of the angiotensin III –mediated up-regulation of the TGF-beta release and expression.
Hexarelin Anti-Atherosclerotic Activity
Anti-atherosclerotic activity of hexarelin can be elucidated on the adult Sprague-Dawley rat. These rats were subjected to the peptide administration and formation of the atherosclerotic plaques and neointima were reduced effectively. In addition, the peptide reversed the serum low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio. On the contrary, there was an increased level of serum nitric oxide and the expression of messenger RNA of the enzyme nitric synthase, CD 36 and growth hormone secretagogues on the subjects. In addition, the treatment of hexaralin decreased the level of tritiated thymidine incorporated on the cultured vascular smooth muscle cells. The peptide reduced the formation of calcium sedimentation on the aortic wall.
Effects of Hexarelin on Cardiac Receptors
The cardiovascular activities of hexarelin can be attributed largely to growth hormone. This mainly occurs through the activation of the cardiac receptors. Earlier studies revealed that the peptide receptors were not shared by the growth hormone releasing hormone. This indicated that they were not mediated by the level of growth hormone. The peptide exerted its effects on the LVEF and it helped in preventing cardiac damage.
Principle of Action
The mechanism of action of hexarelin is not yet fully understood by researchers. However, this is one of the peptides that can act on the hypothalamus and pituitary glands. Moreover, it can marshal the release of higher amounts of growth hormone than any other growth hormone releasing peptide.
Studies revealed that some hexarelin side effects include an increase in mitosis, increase in bone mineral density, meiosis, connective tissue, improved skin elasticity, and fat loss. The benefits of the peptide include an increase in lean body mass, fat reduction, anti-ageing properties and an increase in bone density. However, hexarelin side effects include an increase in prolactin levels, decreased libido, possible gynecomastia, increased cortisol levels.
Hexarelin is delivered as dried powder just like any other growth hormone hexapeptide. It should be stored in a cool dry place like a refrigerator. When reconstituting it for injection into test subjects, bacteriostatic water should be used. Research showed that a combined vial of hexarelin and another growth hormone releasing peptide produces enhanced potency, effectiveness and efficacy.