Melanotan.1

Melanotan 1

$34.89

A synthetic analog of the natural melanocortin peptide hormone alpha-melanocyte that stimulates hormone (α-MSH).

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Product Description

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Melanotan 1, melanotan or simply afamelanotide is a commercially manufactured hormone and is a splice variant of a naturally-produced hormone called alpha melanocyte hormone or alpha-MSH. The alpha melanocyte stimulating hormone is a crucial hormone as it is important in accentuating the release of alpha-MSH from the anterior lobe of the pituitary gland. Without the hormone, the body cannot synthesize melanin or black skin pigment which is essential in protecting the skin from exposure to harmful ultraviolet x-rays.

The activity of the peptide is through biomimicry or activation of the natural system to produce the hormone to work on the target organ. Tanning is a process which the skin converts eumelanin to melanin or a black pigment and works to trapharmful x-rays from the sun. It is essential to note that melanotan should not be confused with melatonin. Melatonin is a hormone that regulates circadian rhythms and sleep patterns. On the other hand, melanotan is important in accentuating pigmentation of skin and it is under research for its effectiveness.

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Melanotan 1 has numerous benefits
Melanotan 1 has numerous benefits

Melanotan 1 has numerous benefits and it is currently under research for potential benefits of using it to find solutions to some problems. The peptide has all the essential features that make it a study material and has gained popularity among researchers and science scholars. Melanotan has a molecular weight of 1.65-kilo Daltons and a formula of C78H111N21O19. Scientists from the University of Arizona who were looking for a cure of melanoma or skin cancer, are credited with the discovery of the peptide. 

Important Facts about the Melanocyte Stimulating Hormone

The hormone alpha-melanocyte stimulating hormone works by stimulating the melanocytes which is a group of peptide hormones synthesized by the epidermal cells. In addition, the peptide hormones synthesized in other parts of the body such as the hypothalamus and pituitary gland, technically the MSH, stimulates many hormones rather than a single hormone.

UV rays from the sun trigger (MSH) hormone
UV rays from the sun trigger (MSH) hormone

Ultraviolet rays from the sun trigger the production of the melanocyte-stimulating (MSH) hormone. The melanocyte-stimulating hormone plays an important role in the production of melanin in the skin and production of pigment in the eyes and the hair. The MSH works by inducing cells on the skin called melanocytes to begin producing melanin. The process requires the sun and it results in the conversion of eumelanin to melanin. Melanin is an important component in the skin of humans. Without it, people would lack skin tone or pigmentation.

production of melanin within the skin cells
production of melanin within the skin cells

Melanin is essential because it has protective qualities and shields the skin cells from DNA alteration and damage. Once the DNA on the skin is altered, it results in cancer or unprecedented multiplication of cells on the skin. Research shows that melanotan 1 is crucial in accentuating deep self-tanning. This is mainly because it triggers the production of melanin within the skin cells. An increase in the production of melanin in the skin is crucial in a biological system because it helps maintain a balance in the level of melanin. This helps in preventing exposure to ultraviolet rays.

Melanotan 1 Mechanism of Action

Melanotan 1 is an analog of melanocyte stimulating hormone, synthesized within the pituitary gland. The peptide is classified as a melanocortin and all melanocortin usually act on a certain physical system that influences sexual arousal, skin pigment and hair color, among other features. When melanin is produced in large quantities, the skin becomes darker and this helps reduce chances of skin cancer.

Tanning process
Tanning process

The mode of action of melanotan 1 is through mimicking the natural skin tanning process. This was the first peptide synthesized by scientists from the University of Arizona. It was called afamelanotide, later melanotan and currently melanotan 1. During the study, the scientists were looking for a solution for skin related conditions, especially melanoma. The study was focused on the naturally-produced hormone alpha melanocyte stimulating hormone. It was during the study that they came up with afamelanotide, which is now melanotan 1. Recent studies showed that the biosynthetic analog of the MSH is a thousand times more potent and effective than the natural hormone.

Melanotan works by triggering various signaling cascades which lead to the activation of melanocortin receptors. The receptors are important because they trigger the release of melanin from the melanocytes. The binding of the peptide to melanocortin receptor 1 or MC1R on the epidermis causes a significant reaction change in the biological system and this results in the production of eumelanin.

In this case, eumelanin is a black or brown photoprotective pigment and the pathway, which is involved in the activation. The pathway usually involves the activation of receptors and when melanotan binds to the receptors, the production adenylate cyclase is activated. The activation adenylate cyclase leads to the production of cyclic adenosine monophosphate or CAMP.  Cyclic adenosine monophosphate is essential because it activates protein kinase A or what is known as PKA.

protein kinase A is activated
protein kinase A is activated

When protein kinase A is activated, it causes the induction and activation of a phosphate group on the adenosine monophosphate and this in turn causes the addition of the molecule to the cyclic adenosine monophosphate response elements or CREB. The phosphorylation of the CREB causes the binding of the molecule to the microphthalmia transcription factor gene. This binding causes the synthesis of MITF protein. The MITF gene is essential for the activation of the melanocortin 1 receptor genes which  is a vital component in melanogenesis.

Mode of Delivery

In most scientific research projects, melanotan 1 is delivered through injection,. The injection can be intramuscular, intravenous or subcutaneous. Melanotan 1 has a half-life of 30-60 minutes according to research conducted on mice. It is imperative to note that the vials used should be sterilized and the water should be bacteriostatic.

Possible Side Effects

Possible Side Effects
Possible Side Effects

Apart from uneven tanning experienced by some of the test subjects, melanotan 1 showed some side effects on the mice in the research project. Melanotan 1 is a milder iteration of the second-generation peptide called melanotan 2. One of the side effects of melanotan 1 is slow development of tan. The tan could take weeks to months in some cases, depending on the response of the test subject. A deeper tan is experienced after injecting a copious amount in the test subject. In most cases, mice and guinea pigs are used for the research. The research findings indicate that melanotan 1 should be injected for a few weeks and observations noted on a daily basis. Other postulated side effects include nausea although this can be challenging to identify. There can also be freckles or flushing of the skin.

Melanotan 1 Functionality

Melanotan 2 and melanotan 1 are both synthetic analogs of the alpha melanocyte-stimulating hormone and are produced in the cells of the pituitary gland. Research showed that the peptide causes an increase in appetite, enhanced libido and sexual arousal. All these are findings from research conducted on mice. Once melanotan 1 was injected, there was an increase in food consumption.

The female mice had solicitation behaviors and reddening of their sexual organs. The males looked for females with lordosis observed. These are scientific research findings and under no circumstance can the peptide be used on humans. The analogs of the peptides are still under research to determine their potency and efficacy in accentuating a certain desired effect.

When the skin is exposed to ultraviolet rays, the reactions observed include actinic keratosis or AKs and polymorphous eruptions or what is referred to as PLE. These conditions often result in lumps, severe sores, dry growths, lesions, burning sensations and patches on the test subject.

In most cases, these  results are observed as the alpha-melanocyte peptide produces the hormone but the receptors fail to respond or do not bind to the peptide. When the levels of the alpha-melanocyte stimulating hormone are increased, they usually have no effect on the overall functionality or response to the peptide.

Melanotan 1 Functionality
Melanotan 1 Functionality

However, research shows that the receptors can be activated with the use of melanotan 1. This is a new development and researchers are still looking for methodologies and potency of the peptide by conducting experiments on mice and guinea pigs. Research findings show that melanotan 1 has the ability to increase the level of pigmentation without the need to expose the skin to harmful ultraviolet rays. The sunless tanning principle of the peptide is an area that has attracted research. It is important to note that the process of skin pigmentation is often accentuated by ultraviolet light. Although the injection of melanotan to the test subject may not cause even tanning, the half-life and the distribution of the peptide are some of the other factors for consideration as well as the response of the body to the peptide.

Recommended Cycles

According to recent research, administration of melanotan 1 through injection often results in some contraindications such as site reactions, fatigue. It does, however, change the blood chemistry of hematological parameters of the blood. It is important to note that when conducting any scientific research using the peptide, look for ideal conditions in all factors.

This is important because it reduces the chances of side effects and alteration of results. Moreover, using peptides that are certified or from a certified vendor is important because some peptides sold in the market are laced with other components such as mannitol. Laced peptides cannot be used to benchmark any scientific study because the standard deviation and the precision of the results are already affected.

Dosage

Dosage
Dosage

Findings from recent research studies indicate that the peptide has to be used for an extended period before the desired result is seen. The dosage may vary depending on the test subject. However, the recommended dosage is usually 2-3 mg per day and depending on the level of activation and production of melanin on the skin. It is essential to note that the system can reach the maximum limit.

Once this limit has been achieved, any further addition of melanotan 1 will not cause any significant effect or any change to the test subject because the optimal production of the pigment has been reached. The peptides in the market are usually supplied in freeze-dried vials or as a white lyophilized powder in a sealed multi-purpose vial.

It is essential to note that melanotan 1 is susceptible to change. Some parameters to look out for include pressure and temperature. The peptide should be transported in an ice pack and the parameters monitored carefully. For research purposes, it is imperative not to underestimate the effects of a parameter change on the overall result.

Once melanotan 1 has been received, it is important that you keep it in a freezer. The preparation of the peptide should be done with bacteriostatic or saline water. You can use 1ml  peptide to 5ml of bacteriostatic water depending on the concentration you want to get. The concentration largely depends on the amount of water used in the process.

For example, if you want to prepare a concentration of 10 mg/ml, then you will have to use 10 mg of the peptide and 1 ml of water.

The concentrations for research purposes usually vary and the commonly recommended dose is 0.25 mg. It is important to note that a further dilution can help you monitor the efficacy and how the test subject will respond to different concentrations. Research shows that melanotan 1 is unstable and it should be reconstituted as and when needed and not reconstituted and stored for future use.

Ideally, a reconstitution of the 10mg vial should be used for a maximum of ten days to avoid damage to the peptide caused by instabilities. Further research studies are being conducted to determine the efficacy and potency of melanotan 1 and it is essential that you get a high quality and certified peptide for research.

Additional Information

Weight 0.005 g