Buy Melanotan 2, (ii) Purchase quality (MT2) Peptides Online
Melanotan 2, melanotan II or simply MT-2 is a synthetic variant of the naturally-occurring hormone, the alpha melanocyte stimulating hormone (MSH). The peptide plays a crucial role in accentuating the development of melanin on the epidermal layers of the skin. Melanotan 2 induces melanogenesis which is a natural process that aids in the formation of pigments in the skin, hair and eyes.
Melanotan 2 is a biosynthetic hormone that is the second generation of the alpha melanocyte stimulating hormone and was produced after the discovery of melanotan 1. The hormone plays a crucial role in initiating a signaling cascade that is essential in melanogenesis which is a process that promotes skin pigmentation. Skin pigmentation is important because it prevents uneven multiplication of skin cells.
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Unprecedented multiplication of skin cells can result in a common problem known as melanoma or skin cancer. This is mainly caused by harmful ultraviolet rays. The peptide alpha-MSH stimulates a signal transduction which causes a movement in the peptide production and the accentuation of melanogenesis mechanisms. The activation of melanocortin receptors is important in bringing about the desired change. When the receptors are activated, they have a positive feedback mechanism on the working principles of appetite, lipid metabolism and libido.
There are numerous benefits of melanotan peptide including suppression of appetite, lipolytic properties and tanning of the skin. Currently, there are various research programs focused on understanding the efficacy and the potency of melanotan, especially in tanning and suppression of appetite. The ability to induce sunless tanning is a major benefit of the peptide and it is important because it prevents an unprecedented growth of cells on the skin. Research indicates that the peptide has the ability to induce sunless tanning and it is very vital in preventing various complications normally caused by ultraviolet rays.
Recent research indicates that the melanotan peptide has the ability to induce sexual arousal, especially in males, as seen in male mice. The peptide was injected into male mice and then observations were made. During the research the male mice were active, showed sexual arousal and sought for females with solicitation behaviors.
The research is ongoing because the efficacy and potency of the peptide have not been known. Researchers have to look and the dimensions in finding the best peptide that can induce the same effect. Melanotan 2 is a polypeptide with amino acid sequence Ac-Nle-cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH2. This peptide was created after the identification of melanotan 1 by researchers at the University of Arizona.
Melanotan 2 is a polypeptide with amino acid sequence Ac-Nle-cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH2. This peptide was created after the identification of melanotan 1 by researchers at the University of Arizona. Melanotan 2 is an improved version from melanotan 1 because its overall molecular weight and the number of amino acids in its chain have reduced greatly. The reduction in the number of amino acids and density of the peptide means that it can penetrate through cells and tissues easily to the target organ.
The researchers at the University of Arizona were looking for an option to create a peptide with an improved efficacy and potency and they came up with melanotan 2. The objective of the research study was to find a peptide that can induce sunless tanning without altering the working biological systems. The main focus was to reduce the overall weight of the peptide by using the most active part and alleviating other amino acids that were unnecessary to the chain.
The half-life of the peptide plays an important role because it determines the longevity that is needed to cause tan. This is important because it will reduce the time taken to induce tanning and reduce the overall chance of developing skin cancer. Melanotan 2 consists of seven amino acids in the chain. It is imperative to note that it has been modified from a linear to a cyclic peptide.
Melanotan 2 activates the central melanocortin receptors and this is essential in initiating a signaling cascade to the melanogenesis process. Research findings indicate that it reduces the cholesterol and serum insulin on the test subjects. However, it does not have a major impact on acetylcholine.
Acetylcholine is an important component in signal transduction and it is essential to know that the inhibition of the peptide can delay relay of information from one part of the neuron to the next. The molecule is inhibited by palmitoyltransferase 1 and carnitine.
A combination of the melanocortin peptides is essential for accentuating various components of the biological system. The alpha melanocyte-stimulating hormone is known to be and a nonselective agonist and it binds to receptors such as MC3R, MC4R, MC1R, and MC5R. Other peptides usually bind to the five melanocortin receptors and melanotan 1 is under investigation to determine how it binds to the receptors effectively. The process of pigmentation or melanogenesis is usually stimulated by the presence of ultraviolet rays. When ultraviolet rays strike the skin surface, it causes a signaling cascade which results in the conversion of the eumelanin to melanin. There are various metabolic pathways which are essential to inducing the production of melanin from the epidermal layers of the skin.
Mechanism of Action
When the peptide binds to the receptor, it induces the production of adenylate cyclase. The production and the activation of adenylate cyclase induce the production of adenosine monophosphate. When the cyclic adenosine monophosphate is produced, it causes the activation and the production of an enzyme called protein kinase A or PKA.
This is one of the essential processes in a biological system because it leads to the activation of a phosphate group on the adenosine molecule. This, in turn, is added to the cyclic adenosine monophosphate response binding element or CREB. The phosphorylation of CREB causes the binding of the cyclic adenosine monophosphate response element to the microphthalmia transcription factor gene. The binding is important because it leads to the activation of receptors such as MC1R, an important process for melanogenesis to occur.
Melanotan 2 and Exposure to the Sun
The tanning process of the alpha melanocyte stimulating hormone is often beneficial in most cases because it prevents melanoma. However, research shows that the injection of melanotan 2 to test subjects induces a sunless tanning. The reports show that the peptide causes tanning much quicker and the tan achieved is a more natural color than what is perceived as synthetic. Studies reveal that maximum tanning occurred on test organisms after the third injection. It is important that while conducting the research that the test organisms are not exposed to ultraviolet rays which will hamper the final result because it will induce a natural production of the tan.
Melanotan 2 and Weight Loss
Melanotan 2 is an effective peptide in promoting weight loss in test organisms, according to research. When the peptide was injected on research guinea pigs, it caused a change in fatty acid oxidation via the alteration of the total fat content in the system. The central melanocortin program is essential because it determines the amount of food ingested by the test organism and it has an immediate effect on the deposition of fats on the peripheral and visceral organs.
There is evidence from the research conducted on mice that the peptide is effective in reducing fats deposited in peripheral cells. The mechanism of action is through an increment in accentuating the response to leptin, a protein which determines satiety. When the peptide is not regulated, it may result in an increased food intake. The increased food intake results in excess weight and this is deposited in the peripheral cells.
Fatty acid oxidation is an important mechanism in reducing the fat content in the system. When leptin resistance is reduced, the overall fat burning mechanism is improved and weight loss is achieved. Food intake and homeostasis play a major role in melanocortin control. Research on mice shows that when melanocortin control is regulated then overall weight.
When melanotan 2 is injected, it increases the response of the test organism to leptin. The peptide initiates a signaling cascade which is dependent on the sensitivity of the receptors to the hormone. Deposition of fats on peripheral organs is one of the main causes of weight gain. However, the peptide reduces this by increasing sensitivity to leptin. The biological system will then respond by cutting nutrient and blood supply to the fat cells or adipocytes. A cut in supply of nutrients and blood supply to fat cells in the peripheral and visceral organs will result in weight loss.
When the supply of nutrients and blood is no longer available to the fat cells, they die off and are released during excretion through the mitochondria. Melanotan has shown a significant effect in reducing the overall number of cells. It is imperative to note that these are research conducted on mice and monitored on a daily basis.
Features of Melanotan 2
Melanotan 2 is an analog of the alpha-MSH and being an analog of the alpha-MSH, the peptide can effectively reduce the various effects and conditions caused by overexposure to the ultraviolet rays. Research conducted on mice with a condition such as polymorphous keratosis and actinic keratosis showed that the peptide accentuates the regeneration of new cells and the development of a better mechanism to combat the further deterioration of the system.
These conditions are usually caused when there is a reduced production of the alpha-melanocyte stimulating hormone or the receptors have failed to respond to the production of the hormone. A loss in functionality or the response of the peptide to the elements will result in no activity. Melanotan 2 initiates the process by increasing the response of the receptors and positioning the ligand in a way that they will perfectly fit the receptors. Studies conducted concluded that the peptide is efficient because it mimics the natural production of the alpha melanocyte stimulating hormone from the anterior lobe of the pituitary gland.
Recommended Research Dosage
There have been numerous research and studies conducted on melanotan 2 and the findings have been largely dependent on the dosage administered. The administration of a certain dosage can be effective on one while there is no significant effect on the other.
Research done on mice shows that the peptide causes fatigue and site reactions. However, the hematological parameters and blood chemistry remain unaltered. It is imperative that when conducting any medical or scientific research that the peptide should be of a known potency and a quality grade. The melanotan 2 purchased should give comprehensive results that are in tandem with modern research and development. Benchmarking of studies cannot be done if the peptide has been laced with other additives such as mannitol.
It is essential that when the researcher is purchasing the peptide, a certificate of purity is provided. The regular dosage that elicits a reaction is 2-3 mg per day and depending on the activation level of the test organisms, the dosage may be reduced or increased.
It is important to note that there is a maximum limit of the dosage. When it has reached the highest concentration, adding more will not have any effect. When the limit is reached, any addition will not cause pigmentation. The peptide is often supplied in freeze-dried vials or lyophilized vials and it should be kept in a refrigerator at -8 degree Celsius or as per the instructions on the packaging label.
It is vital to know that any change in temperature and pressure will affect the potency and the efficacy of the peptides because most amino acids are sensitive to changes in these parameters. Always reconstitute a peptide of a known concentration and for use in one or two experiments. This helps in reducing contamination and efficacy of the peptide. The peptide should be kept in a refrigerator and should be monitored on a daily basis. The second generation of melanotan is the most effective peptide in inducing sunless tanning, especially on the research mice as studies have shown.