PT-141

PT-141

$37.89

A cyclic hepta-peptide lactam derivative of alpha-MSH that stimulates melanocortin receptors present in the central nervous system.

Product Description

Buy PT 141 Peptide Online for Precise Research Result

pt-141
pt-141

Bremelanotide or pt 141 is a commercially produced version of alpha-MSH ( melanocyte-stimulating hormone). The peptide is synthesized endogenously.

The alpha-MSH has numerous effects in a biological system, most of which include enhancing libido, lipid metabolism and appetite. According to pt 141 review, the peptide is seen to act on specific receptors such as the MC4R and MC3R.

The peptide is under research investigations to determine its activity as a remedy for sexual dysfunctions, hemorrhagic shock, and reperfusion injuries.

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About bremelanotide

bremelanotide-vial
bremelanotide-vial

Melanotan 2 predecessor, bremelanotide or Melanotan 1, has undergone numerous testings in determining its effectiveness in inducing sunless tanning. Moreover, the peptide has been known to cause sexual arousal and spontaneous erections on the test mice subjects.

Research done on mice indicated that the pt 141 peptide has positive feedback on sexual dysfunctions such as erectile dysfunction in male rats and arousal disorders in female rats. The application of the peptide can vary from subject to subject.

It can be applied intravenously, through the nasal cavity and orally. There are some side effects expected from the administration of the peptide and one of them is an increase in blood pressure. According to different reviews on pt 141, it is touted as the most effective aphrodisiac. However, all these information is still under scrutiny.

The peptide is essential in increasing libido and it acts on the central nervous system and not the vascular system as other common peptides do. The target of the peptide is the brain arousal center and it affects an increase in libido through the activation and stimulation of the melanocortin receptors. According to research, test mice showed an increase in blood flow to the reproductive organs. In female rats, they became active and looked for their male counterparts.

The peptide has shown activity from 6-72 hours. The peptide is supplied in vials of 10 mg which  is the industry standard. However, for research purposes, the peptide can be supplied in 2 mg vials which are convenient for transit.

The peptide is supplied in powder form or freeze-dried form and should be kept in 2-8 degree Celsius to ensure that its integrity is not interfered with. Most peptides are sensitive to changes in temperature and pressure. A 10-milligram vial can supply up to twenty doses on the research subject which is enough for making some conclusions.

A high quality should be reconstituted using bacteriostatic water or saline water and it should be stored in a freezer when not in use. The test dosage is usually 0.25 milligrams to 0.5 milligrams. However, the dosage can be increased up to 2 mg can be done to elicit the required reaction.

The peptide is currently under investigation for handling different problems such as reperfusion injury, hemorrhagic shock and sexual dysfunctions. The main objective of the study is to identify the effects of the peptide in the stimulation of sexual arousal in women and erectile dysfunction in men.

According to the study done on mice, hops and darts, heart racing and soliciting sexual behaviors were seen and brain assessment confirmed the postulate. Using special molecular markers the heightened activation of the mice sexual activity, the results showed that the hypothalamic and limbic regions in the mice were activated and the mPOA, terminals were activated. This led to an increase in the levels of dopamine in the brain.

Mechanism of Action

Mechanism of Action
Mechanism of Action

The pt 141 review indicated that the peptide has seven amino acids in its sequence and it is a cyclic molecule, therefore, a lactam derivative. The peptide acts through the stimulation of melanocortin receptors situated in the central nervous system.

The peptide has the potential of growing to be one of the most sought after since it has numerous beneficial features that are still under investigation. There is a high possibility that after approval, the peptide could be used to treat arousal disorders and erectile dysfunctions.

The peptide has a molecular weight of 1.025-kilo Daltons. In addition, the peptide is not a vasoactive compound – it directly acts on the CNS to elicit the desired reaction. In the past, there have been many studies that tried to identify the possibility of using the peptide to treat numerous conditions.

The peptide works as an agonist to the melanocortin peptide hormone and it is known to activate the MC4R and MC3R receptors. The hormone is important in stimulating the conversion of eumelanin to melanin on epidermal cells of the skin in a process referred to as melanogenesis. This is an essential biological process because it aids in avoiding skin cancer and other associated conditions.

Pt 141 Features

pt-141-features
pt-141-features

The peptides activate the melanocortin receptors. This in turn has positive effects on libido, appetite and lipid metabolism. According to PT 141 research , the peptide is important in the tanning process and it does not require any kind of exposure to harmful UV light.

On the other hand, the peptide is important in inducing lordosis and it is showing a high effect in becoming a remedy to sexual dysfunctions in men and women. The mechanism of action is through the stimulation of melanocortin receptors in the CNS and these receptors are essential in limiting and modulating the possibilities of developing ischemia.

Further studies are being conducted on the possibility of using the peptide as a smoothing agent. In this context, the peptide can be applied on the vaginal walls and this will in turn alleviate arousal problems. Pt 141 allows researchers to conduct all the research required before it is allowed for use in any other purposes. The research is mainly focused on the libido and sexually related functions of the peptide.

It is observed that the administration of the pt 141 peptide acts on the central nervous system and induces tingling sensation, excitement and throbbing, among other sexual related characteristics.  As per pt 141 reviews, it is supplied in 10 mg vials and 2 mg is often used in research.

As indicated earlier, storing the peptide in a freezer when not in use is an important process in keeping its integrity intact. You can use 0.25 to 0.5 milligrams of the peptide on the test mice or guinea pig subjects in the first attempt. You can increase the dosage until the desired effect is achieved.

After 4 hours of administration, the peptide will peak in its activity and will bring the desired effect and alleviate the problem. The peptide is available in numerous forms such as nasal sprays, pre-mixed versions and pills, among others.

Effects of Pt 141 on Sexual Dysfunctions

sexproblemcircles
sexual dysfunctions

Penile erection is one of the most complex physiological processes. Understanding it will help in knowing how the peptide works.  Activation of the receptors in the CNS causes blood to rush to the gland. This in turn causes an erection. According to pt 141 reviews, the peptide has shown the ability to initiate spontaneous erections.

While the CNS may act on the MC3R and MC4R, there are numerous postulates which differ on the receptor that is responsible for causing an erection. This inconclusive result is mainly because the activity of MC3R is not well-elucidated. New research shows that the peptide causes antagonism of the MC3R on the brain.

The peptide has positive feedback in causing the erection. It acts on the oxytocinergic pathways in the brain stem, spinal and hypothalamic levels. The manipulation of melanocortin receptors is the new method of dealing with erectile dysfunction and this will provide a new approach in dealing with sexual dysfunction problems.

The melanocortin cholinergic system is essential in the mediation of various complexes and a wide variety of physiological effects . These may include salt regulation, skin pigmentation, penile erection, food intake regulation and sexual behavior.

There are numerous effects which occurs through the selective activation of 5-receptor subtypes. These are unique for the post-translational modification of the postprandial proopiomelanocortin gene. There is a high chance that the peptides will be beneficial in understanding various subtypes and how they will be used in modern drug research and drug design.

The sub types include beta MSH, ACTH, gamma MSH and alpha MSH. In the novel testing for a synthetic agent for tanning, the peptide resulted in an 8-hour long erection on the mice under study. It is believed that the activation of the melanocortin receptor by the peptide induced the erection.

Pt -141 reviews indicated that normal erection occurs when the peptide is administered. However, the longevity may differ depending on the type of the receptor activated.

The supraspinal regions are activated and these in turn activates the parasympathetic and the sympathetic centers resulting in sexual behaviors. The neurotransmitter modulating the erection via the nitric oxide release the non-cholinergic and nonadrenergic nerves which activate the cavernosal smooth muscle cells to guanylyl cyclase.

The enhanced production of cyclic nucleotide guanosine monophosphate and this results in cellular relaxation via calcium regulating channels and this activates ejaculation. All the peptides supplied are for research purposes only and human consumption is prohibited.

PT-141 and Hemorrhagic Shock

hemorrhagic-stroke
hemorrhagic-stroke

One of the focuses of the scientific study based on animal test subjects is to determine the link between pt-141 Bremelanotide and the serious condition of hemorrhagic shock.

Essentially, the condition itself is marked by lower tissue perfusion which over time turns in an inadequate delivery of oxygen and nutrients that are vital for cellular function. The condition is split into four classes: neurogenic, cardiogenic, hypovolemic and vasogenic which is better known as septic.

Overall, it is a very tricky ailment to deal with when it’s observed on a cellular level. That’s because no two cells will express the exact presentation of shock identically.

Scientific study based on animal test subjects has shown that pt-141 Bremelanotide design is to stimulate the neural reflects as a method to regulate blood flow through organs that would otherwise slow down or even shut down as a result of hemorrhagic shock. This particular manner of stimulation can be manifested in several ways:

  • A boosted heart rate
  • Vasoconstriction
  • A redistribution of blood flow away from organs that an animal test subject would deem to be unnecessary for ultimate survival, such as the skin or the kidneys

PT-141 Bremelanotide and Reperfusion Injury

mediators-of-lethal-reperfusion-injury
mediators-of-lethal-reperfusion-injury

Another main area of scientific study that has been based on animal test subjects is to determine a link between pt-141 Bremelanotide and its conceived ability to lessen the effects of reperfusion injury.

In essence, a reperfusion injury refers to the type of tissue damage that could be caused in the wake of an ischemic episode such as a stroke or angina pectoris.

When this condition happens, a process that is normally considered important – the circulation of blood flow through an organ – actually results in oxidative damage and inflammation via the condition of oxidative stress.

It has been determined via a scientific study on animal test subjects that pt-141 Bremelanotide can work on a neurological level to lower the inhibitions that would otherwise be linked to the restriction of blood flow to tissues as a result of the ischemic cascade.

The ultimate result of this process would translate to a lowering or even a blockage of any and all resultant damage that may otherwise happen from blood flow limitation to potentially affected areas.

Other Focuses of Study

alpha melanocyte stimulating hormone
alpha melanocyte stimulating hormone

While studies of pt-141 Bremelanotide and its respective links to hemorrhagic shock and reperfusion injury are the most prominent fields of study regarding the peptide, it should be noted that some studies in relation to the peptide has been focused on discovering a link between it and sexual dysfunction in both male and female animal test subjects.

Pt 141 peptide is effective in accentuating the release of alpha melanocyte stimulating hormone. It is essential in the release of new cells in the nuclei and this is essential especially for reperfusion injuries as indicated earlier.

Studies have shown that the peptide is under investigation for its potency and efficacy in releasing the melanocyte hormone that is essential in the growth of new cell lines. Cell lines promote growth and development in cells and tissues.

Additional Information

Weight 0.005 g