A synthetic form of Thymosin Beta 4 that occurs naturally in animal cells used to improve differentiated endothelial cells functions and associated physiological roles.

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Product Description

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The thymus gland is an important gland and peptide that is essential in the production of hormone thymosin. The main function of the hormone is to induce the production and stimulation of T-cells.

T-cells are essential in maintaining the body’s immune system as well as fighting of pathogens. Moreover, the peptide is crucial in the development of beta cells into plasma cells. This is an important process because it leads to the production of antibodies. A common form of thymosin is thymosin beta 4.

This is one of the popular peptides and a member of actin monomer sequestering proteins. Beta-thymosin is one of the main regulators of non-polymerized actin and it is important in maintaining the required amount of free G-actin monomers which are important in the elongation of filaments.

Moreover, it allows for the influx of monomers between the F-actin and thymosin pool. TB-500 is a synthetic version of the natural thymosin beta 4 and the peptide is produced in the thymal gland. The peptide is important in differentiation of endothelial cells as well as their proliferation and optimal functioning.

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Cell proliferation and maturity is one of the essential procedures as it ensures that there is a growth of new dermal tissues and cells. These replace dead cells. Recent research indicated that thymosin beta 4 plays a crucial role in the deposition of collagen and accentuates the migration of keratin cells to the peripheral organs, thereby decreasing inflammation on the site.

TB-500 is still under research on its activity as well as its effectiveness and potency in actin regulation. Actin is one of the most important proteins and it makes up a tenth of total proteins in the system. It has a positive impact on the expression and development of gene formation. The cells bind to the receptor and this causes the actin sequestering molecules in the eukaryotic cells to block actin polymerization.

TB 500 and Blood Vessel Formation


Research indicated that the TB 500 peptide up-regulates the blood vessel formation by up to 5 times. The formation of these new blood vessels is important because it ensures that blood and oxygen are delivered to different parts and organs of the body.

The amino acid binding is important in the production of extracellular matrix degrading enzymes and the migration of cells to the cytoskeleton. The migration of endothelial cells and keratin is accentuated by the TB-500 peptide and matrix-degrading enzymes which acts as catalysts to the entire process.

trigger the repair and regeneration process
trigger the repair and regeneration process

There are forty amino acids in the structure and these amino acids are important in the specific way. They trigger the repair and regeneration process. This is one of the most prominent differentiating features between the peptide and other hormones because it can maneuver through cells and tissues with ease and comfort. With recent studies revealing that, the TB-500 peptide has up regulatory mechanism in the genetic formation of protein materials that are important in the formation of blood cells.

TB – 500 is important in accentuating the healing of damaged cells. Additional studies indicated that it plays a crucial role in myoblasts formation, muscle recovery and repair of damaged tissues. TB-500 is an improved version of the natural thymosin beta 4. It has cell formation and anti-inflammatory properties and its main function is to promote synthesis of present proteins, among others.

The versatility of the hormone can be contributed to its structural conformation and low molecular weight – this allows the peptide to move through cells with ease and comfort. Studies are still underway to determine the effectiveness of the peptide in alleviating different conditions such as chronic pain, acute conditions, among others. Some postulated benefits of TB-500 include enhanced flexibility, reduction of alopecia and reduced inflammation, among others.

Principle of Action


Thymosin beta 4 is a naturally occurring peptide and is available in nearly all animal and human cells. TB-500, on the other hand, is a peptide that is linked to recovery because it aids in the building of new blood vessels and tissue fibers. In addition, the peptide plays an important role in cell migration and cell reproduction.

The mechanism of action of TB-500 is via the up-regulation of cell-building proteins such as actin. When the peptide is up-regulated, it promotes cell proliferation and migration, a process that is beneficial to the building and repair of tissues. The peptide is used in a condition where there are acute injuries or when there is an immediate muscle tissue recovery required.

It is important to note that all these experiments are still at the research level. Recent research showed that some injuries can be alleviated by the use of the peptide. These may include tendinitis, muscle tears as well as strains, muscle and connective tissue related injuries.

Combination of TB-500 with Other Peptides


There are numerous positive effects when TB – 500 is combined with other peptides. This is important in the production of beta cells. Modification of the peptide via a combination of other vials such as modified GRF, GHRP-2, hexarelin and other peptides is important in enhancing the peptides efficacy, potency and effectiveness.

Just like any other peptides, TB-500 is supplied in lyophilized or freeze dried powder of between 2 milligrams to 10 milligrams. It is essential to understand that for best results to be achieved, you should add only the required amount of the peptide rather than the whole vial. Reconstitution of the peptide should be carried out using sodium chloride or bacteriostatic water and a typical insulin syringe can be used for experimental purposes.

This will not affect the quality and it delivers optimal results. The common form of administration is the induction of 2 mg to 2.5 milligrams of the TB-500 peptide for 14 days. Thereafter, the dosage is lowered to see the effect of the peptide on the test subject.

Pharmacology of TB-500


Thymosin beta 500 is a short fragment of the natural hormone thymosin beta 4 as indicated earlier. It is essential to differentiate thymosin beta 4 and TB-4 though unscrupulous business people have sold the peptide under that name. In human bodies, TB-4 is produced in the thymus gland. In most cases, the concentration is very high during childhood and thereafter reduces gradually and goes to non-existence in adulthood.

Proteins of the peptide do not bind to the receptor site because it is usually too large to bind to the receptor site. On the contrary, the peptide binds to specific receptor sites in the active region.

TB- 500 has shown the ability to contribute to hair loss via different processes in male pattern baldness. The peptide darkens the part of the hair that has turned grey. In addition, there are research studies to determine the effectiveness of the hormone in increasing the horse’s muscle mass.

TB- 500 has shown the ability to contribute to hair loss
TB- 500 has shown the ability to contribute to hair loss

The latter is mainly because of the accentuation of satellite cells and when these cells are activated, they proliferate and differentiate exponentially, thereby increasing muscle mass. The peptide is distributed in lyophilized powder as indicated earlier and should be kept in a coo, dry place away from sunlight.

Sunlight is known to cause disintegration of amino acids in TB – 500 and this will affect the quality of the result. TB 500 is known to accentuate cell division and cellular differentiation apart from promoting blood vessel formation. In addition, the peptide is important in promoting healing and development of new myoblasts. Healing effects are seen in tendons, muscle cells and ligaments, among other areas.

The peptide is different from other repair factors such as IGF-1 or insulin-like growth factor 1 because it promotes keratinocyte migration. The mechanism of action is the ability to regulate cell protein actin protein, an important aspect in modern studies. Thymosin beta 4 has 43 amino acids in its sequence and is coded by the gene TMSB4X. The peptide is a huge molecule and binds only to the desired area to bring about desired change.

As indicated earlier, bacteriostatic water should be used in the reconstitution of the peptide. On the other hand, sodium chloride can be used to reconstitute the peptide and this is essential as it helps in making a sterile solution that bacteria have no chance of tampering.

dosage of TB - 500 depends on the test sample
dosage of TB – 500 depends on the test sample

It is essential that it should be kept in a refrigerator of between 2-8 degree Celsius. This is important because it ensures that the vial is active and the peptide does not use its activity. In addition, the dosage of TB – 500 depends on the test sample and should only be applied when needed rather than constitute the entire vial. Effects of the peptide vary from subject to subject. It is important to note that the peptides have not been approved by the food and drug administration agencies, therefore, they are solely used for research purposes only.

Effects of TB 500

The main research on the peptide relates to wound healing process. TB 500 has shown to have anti-inflammatory properties coupled with its ability to repair and heal wounds. Research based on animal subjects showed that administration of the peptide increased wound healing capacity by up to 50%.

The peptide is efficient in improving injury recovery process because it stimulates the cells to produce newer cells, replenishing the damaged or the dead cells. Recent research studies showed that the peptide has a vital role in accentuating the growth of muscle tissues. This process can be attributed to the cellular migration experienced once the peptide is administered. Moreover, research done on mice showed that TB – 500 provide muscle flexibility because of its myoblastic activity.


The notion is directly linked to the peptide’s ability to alleviate entry of pathogens to the test organism and accentuation of muscle contractions. Guiding principles indicated that the peptide will allow the animal to experience a range of physical movement and stress without experiencing any type of hyperextension.

Moreover, the peptide boosts angiogenesis or formation of new blood vessels from existing blood vessels, differentiation of blood cells and collage deposition. Studies revealed that the peptide promotes healing of wounds and damaged areas.

This is essential because the peptide will help treat muscle strain, tear and tendon inflammation. In researches when the peptide is administered to mice with injured or inflamed tendons, it is seen to speed up the healing process and the time taken for the wounds to heal is shorter compared to those that were not administered with the peptide. The effects of the peptide can be linked to hair growth.

Studies showed that TB-500 can aid in reversing hair loss. However, these research postulates are still under study and the data that is found is anecdotal.

Side Effects of TB-500

TB 500 peptide has been in used in different research studies and findings indicated that the only side effect known is irritation of the injection site. However, according to the data, once the peptide is administered, the administration site may become sore or numb. However, after sometime, it will heal and the appearance will resume normal. Other symptoms postulated include nausea, headaches, head rushes, among others.

TB-500 Administration


The peptide is supplied in dried or lyophilized form and the researcher has to reconstitute the peptide using bacteriostatic or saline water. The common dose administered during research varies depending on the objectives. However, it is important to note that a dose that brings about change is 2 milligrams to 2.5 milligrams administered twice a week for four to six weeks.

Findings indicated that TB – 500 dose can be reduced depending on the impact or the results achieved during the study period. The peptide can be administered on injured mice and observations made on the progress of healing and the recovery process. It is imperative to note that in most cases, the peptide has a certain limit that even if the concentration is increased, it does not cause any effect.

Additional Information

Weight 0.005 g